1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN-Acetyl-Ser-Asp-Lys-ProCat. No.: HY-P0266CAS No.: 127103-11-1分式: CHNO分量: 487.5Sequence: Ac-Ser-Asp-Lys-ProSequence Shortening: Ac-SDKP作靶点: Angiotensin-converting Enzyme (ACE)作通路: Metabolic Enzyme/Protease储存式: Please store the p
2、roduct under the recommended conditions in the COA.BIOLOGICAL ACTIVITY物活性 N-Acetyl-Ser-Asp-Lys-Pro 是来髓的内源性四肽，是 ACE 的 N-末端位点的特异性底物。体外研究 N-Acetyl-Ser-Asp-Lys-Pro is degraded specifically by ACE, and its plasma level rises substantially during ACE inhibitor therapy. Flow cytometry of rat cardiac fibrob
3、lasts treated with N-Acetyl-Ser-Asp-Lys-Pro shows significant inhibition of the progression of cells from G0/G1 phase to S phase of the cell cycle. Moreover, phosphorylation and nuclear translocation of Smad2 is decreased in cardiac fibroblasts treated with N-Acetyl-Ser-Asp-Lys-Pro 1. N-acetyl-seryl
4、-aspartyl-lysyl-proline appears to exert this function by blocking the action of a stem cell-specific proliferation stimulator and acts selectively on quiescent progenitors 2. N-Acetyl-Ser-Asp-Lys-Pro inhibits collagenase expression and activation is associated with increased expression of TIMP-1 an
5、d TIMP-2. N-Acetyl-Ser-Asp-Lys-Pro normalizes the IL-1-mediated increase in MMP-2 and MMP-9 activities and MMP-13 expression 3.体内研究 N-Acetyl-Ser-Asp-Lys-Pro prevents hypertension-induced inflammatory cell infiltration, collagen deposition, nephrin downregulation and albuminuria, which could lead to
6、renoprotection in hypertensive mice 4.REFERENCES1. Rousseau A, et al. The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specificsubstrate of the N-terminal active site of human angiotensin-converting enzyme. J Biol Chem. 1995 Feb 24;270(8):3656-61.2. Pokharel S, et al. N-acetyl-Se
7、r-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts. Hypertension. 2002 Aug;40(2):155-1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE61.3. Rhaleb NE, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1-mediated matrix metalloproteinase activation in cardiac fibroblasts. Pflug
8、ers Arch. 2013 Oct;465(10):1487-95.4. Rhaleb NE, et al. Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in deoxycorticosterone acetate-salt hypertensive mice. J Hypertens. 2011 Feb;29(2):330-8.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE2/2 Master of Small Molecules 您边的抑制剂师
