1、分子量361.16 溶解性（25C） DMSO 分子式C H N O VWater CAS号675848-25-6Ethanol 储存条件3年 -20C 粉末状 生物活性 VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC= 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTP and SAC (ICvalues are 588 nM, 4.03, 57.5 an
2、d 10 M respectively). Increases PIP and PIP levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated T. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice
3、. 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南） 小鼠大鼠兔豚鼠仓鼠狗 重量 (kg)0.020.151.80.40.0810 体表面积 (m )0.0070.0250.150.050.020.5 K 系数36128520 动物 A (mg/kg) = 动物 B (mg/kg) 动物 B的K 系数 动物 A的K 系数 例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K 系数（3），再除以大鼠的K 系数（6）， 得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。 参考文献 Pharmacological characterization of the human melatonin Melreceptor following stable transfection into NIH3T3 cells. Nonno, et al. Br J Pharmacol. 1998;124: 485. PMID: 9647472. VO-OHpic 目录号M7464 化学数据 121028 50 5023 regs 2 m m m mm 1a
