1、镄刀(崀搀磀崀崀崀讀缁缀尀燗漀螏頀h退椀餂謃范茋茋鼋夋愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀夀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀愀昀愀愀愀挀戀愀愀搀挀戀攀礀礀伀愀愀倀吀琀攀吀焀吀堀砀洀琀圀栀戀匀猀甀瀀砀嘀氀倀焀夀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀昀昀攀挀攀攀搀戀愀愀攀挀挀夀愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀舀舠舀脠丠茀传舀漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀渀琀攀爀氀攀甀欀椀渀刀攀氀愀琀攀搀倀愀琀栀眀愀礀洀洀甀渀漀氀漀最礀渀昀氀愀洀洀愀琀椀漀渀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀嬀
2、崀漀爀漀欀愀琀愀吀攀琀愀氀昀昀攀挀琀漀昀愀渀漀瘀攀氀椀渀琀攀爀氀攀甀欀椀渀爀攀挀攀瀀琀漀爀愀渀琀愀最漀渀椀猀琀夀漀渀愀渀琀椀最攀渀椀渀搀甀挀攀搀攀漀猀椀渀漀瀀栀椀氀椀渀昀椀氀琀爀愀琀椀漀渀椀渀琀漀琀栀攀愀椀爀眀愀礀漀昀洀椀挀攀洀洀甀渀漀氀攀琀琀瀀爀嬀崀漀爀漀欀愀琀愀吀攀琀愀氀昀昀攀挀琀漀昀愀渀漀瘀攀氀椀渀琀攀爀氀攀甀欀椀渀爀攀挀攀瀀琀漀爀愀渀琀愀最漀渀椀猀琀夀搀椀洀攀琀栀漀砀礀搀椀洀攀琀栀礀氀搀椀栀礀搀爀漀戀攀渀稀漀嬀崀椀渀搀漀氀椀稀椀渀漀嬀戀崀焀甀椀渀漀砀愀氀椀渀攀漀渀愀渀琀椀最攀渀椀渀搀甀挀攀搀愀椀爀眀愀礀椀渀昀氀愀洀洀愀琀椀漀渀椀渀一爀愀琀猀渀琀洀洀甀渀漀瀀栀愀爀洀愀挀漀氀甀氀愀甀琀椀漀
3、渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓夀言茀渀7瀀崀箙:贐耀鄀侳堠陰贐胔-q輀%棙i缀$YU238259-DataSheet-MedChemExpress.pdfpic1.gifYU238259DataSheetMedChemExpress.pdf2019-530dba7ed51-5b5b-4aad-8733
4、-e32bfc3dbdf4c9Sk9f0TRauj+i/CQm4QQFoPZ1bKbfz7VOKecE+LHsFeUpyaoPEhjQ=YU238259,DataSheet,MedChemExpress92896a64a197ab31e63944a600091416YU238259Cat. No.: HY-19977CAS No.: 1943733-16-1Molecular Formula: CHClNOSMolecular Weight: 459.95Target: DNA-PKPathway: Cell Cycle/DNA Damage; PI3K/Akt/mTORStorage: 4C
5、, protect from lightSolvent 13(10):1389-97.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2MedChemExpress0001500006先进医疗
6、20190530092425205971Y0櫩陰(崀搀鴀翹崀瀂崀崀讀缁缀燚漀螏頀h退椀贂甃欃欇欇蜇鬇娇愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀娀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀昀搀戀挀昀搀愀愀栀爀眀甀甀欀椀漀礀漀琀欀瘀礀欀圀眀椀甀琀爀伀砀伀匀愀眀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀攀攀戀攀挀愀戀攀昀愀昀昀攀娀愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀脀褠舀萠丠舀传舀匠漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀伀琀栀攀爀猀倀愀琀栀眀愀礀伀琀栀攀爀猀匀琀漀爀愀最攀倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀
7、椀渀琀栀攀伀匀漀氀瘀攀渀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓娀UMI-77Cat. No.: HY-18628CAS No.: 518303-20-3Molecular Formula: CHBrNOSMolecular Weight: 468.34Target: Bcl-2 FamilyPat
8、hway: ApoptosisStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent Bfl-1, Ki: 5.33 M; Bcl-W, Ki: 8.19 M; Bcl-2, Ki: 23.83 M; Bcl-xL, Ki: 32.99 MIn Vitro Competitive binding curve of UMI-77 against Mcl-1 is obtained by FP based binding assay using fluorescent labeled Bid
9、 BH3 peptide with an IC50 of 1.870.22 M. UMI-77 potently inhibits the cell growth of BxPC-3 and Panc-1 cell lines with IC50 values of 3.4 M and 4.4 M respectively, and shows 3 to 5 times less potency in inhibition of the cell growth of two other tested cell lines MiaPaCa-2 (12.5 M) and AsPC-1 (16.1
10、M). The cell growth inhibition potency of UMI-77 correlates with the highest expression of Mcl-1 and Bak, and lowest expression of Bcl-xL in the sensitive cell lines, BxPC-3 and Panc-1. Capan-2 cells are showing similar sensitivity to UMI-77 (IC50 of 5.5 M) as BxPC-3 and Panc-1, although has low Mcl-1 levels1.Product Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1In Vivo UMI-77 exhibits moderate metabolic stability with a half-life of 45 minute
