1、鼀(姃栁匀%！堷椀姛栁姃栁讀缁缀%蠀宔瀀螏頀h頀椀錂范欃欋欋蜋鬋伀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀伀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀愀搀戀戀戀昀挀戀攀搀愀挀攀愀昀愀甀攀昀嘀嘀最刀瘀倀吀眀攀夀攀焀伀爀猀戀戀攀唀最娀攀欀夀眀攀焀倀最伀攀搀栀攀洀砀瀀爀攀猀猀攀挀攀搀搀昀昀戀愀昀愀搀攀搀愀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匀挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀爀琀椀昀椀挀愀琀攀漀昀渀愀氀礀猀椀猀倀夀匀一倀刀伀倀刀吀匀漀氀攀挀甀氀愀爀漀爀洀甀氀愀一伀漀氀攀挀甀氀愀爀圀攀椀最栀琀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀栀攀洀
2、椀挀愀氀匀琀爀甀挀琀甀爀攀一夀吀吀瀀瀀攀愀爀愀渀挀攀椀最栀琀戀爀漀眀渀琀漀戀爀漀眀渀匀漀氀椀搀一刀匀瀀攀挀琀爀甀洀漀渀猀椀猀琀攀渀琀眀椀琀栀猀琀爀甀挀琀甀爀攀匀漀渀猀椀猀琀攀渀琀眀椀琀栀猀琀爀甀挀琀甀爀攀倀甀爀椀琀礀匀漀渀挀氀甀猀椀漀渀吀栀攀瀀爀漀搀甀挀琀栀愀猀戀攀攀渀琀攀猀琀攀搀愀渀搀挀漀洀瀀氀椀攀猀眀椀琀栀琀栀攀最椀瘀攀渀猀瀀攀挀椀昀椀挀愀琀椀漀渀猀倀爀漀搀甀挀琀一愀洀攀愀琀一漀夀匀一漀愀琀挀栀一漀栀攀洀椀挀愀氀一愀洀攀嬀椀瀀礀爀椀搀椀渀攀崀挀愀爀戀漀砀愀洀椀搀攀愀洀椀渀漀一嬀洀漀爀瀀栀漀氀椀渀礀氀漀砀愀稀漀氀漀嬀戀崀瀀礀爀椀搀椀渀礀氀崀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀
3、氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓言茀渀7姞栁栉:X胔-雠輀$棙垠&i缀$CA-4948-DataSheet-MedChemExpress.pdfpic1.gifCA4948DataSheetMedChemExpress.pdf2019-610a5acb9af-6f23-4454-9bbb-1325e5c8b8e2jxDsEw4rl2wBwYNU
4、sAAhTaAJ8e9pUn10ZvUn86Mw0IDOVLmwb1JJAA=CA,4948,DataSheet,MedChemExpresse3ea6fcf15c57d6f008ef1c54385d2dcCA-4948Cat. No.: HY-109585CAS No.: 1801343-74-7Molecular Formula: CHNOMolecular Weight: 417.42Target: IRAKPathway: Immunology/Inflammation; Protein Tyrosine Kinase/RTKStorage: Powder -20C 3 years4C
5、 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent Need ultrasonic and warming)ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 2.3957 mL 11.9783 mL 23.9567 mL5 mM 0.4791 mL 2.3957 mL 4.7913 mLPreparing Stock Solutions10 mM 0.2396 mL 1.1978 mL 2.3957 mLPlease refer to the solubility information to sel
6、ect the appropriate solvent.BIOLOGICAL ACTIVITYDescription CA-4948 is a selective and potent IRAK4 inhibitor.IC April 1-5, 2017;Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park D
7、r, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2MedChemExpress0001500006先进医疗20190610133720329921C0焀(姩栁匀%！脨谀堹椀娄栁姩栁讀缁缀%宙瀀螏頀h頀椀鬂伃伃伃較愀氀昀琀栀礀洀甀猀一匀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀氀昀琀栀礀洀甀猀一匀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀愀戀愀昀戀昀昀愀昀搀戀圀搀夀儀猀一刀吀嘀甀夀栀刀吀椀愀嘀氀樀倀堀漀眀攀娀倀琀娀甀挀挀儀愀氀昀琀栀礀洀甀猀一匀匀攀搀栀攀洀砀瀀爀攀猀猀愀昀挀戀挀昀搀挀搀攀戀昀栀刀K攀搀栀攀洀砀瀀爀攀猀猀靓騝尗缐怍猌贉笐蔀
8、餁頕言茀渀7妉栁:虌fX觐虌胔-謨輀$棙(i缀$BX-912-HNMR-09171-MedChemExpress.pdfpic1.gifBX912HNMR09171MedChemExpress.pdf2019-610a8e4ef75-d019-4a9a-8a9f-df075b3ad971AfLl7qtFh5RMtIE3lkfj4uHj7+h5SScBR9ooDxZv7xJJ3n22HIufjQ=BX,912,HNMR,09171,MedChemExpress8e8409751865e5a72bf54e904691e69(姹栁匀堻椀娆栁姹栁讀缁P退宛瀀螏頀h椀餂謃伋挋欋欋欋錋錋錋錋錋錋錋錋錋錋錋
9、錋錋錋錋錋錋錋锋愀瀀稀椀洀椀渀伀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀瀀稀椀洀椀渀伀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀攀愀愀搀挀愀挀搀吀娀礀圀匀昀嘀氀攀戀焀栀儀伀眀栀倀稀稀一倀吀眀猀焀愀猀愀瀀稀椀洀椀渀伀攀搀栀攀洀砀瀀爀攀猀猀昀昀昀搀戀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匀挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀爀琀椀昀椀挀愀琀攀漀昀渀愀氀礀猀椀猀倀夀匀一倀刀伀倀刀吀匀漀氀攀挀甀氀愀爀漀爀洀甀氀愀一伀匀漀氀攀挀甀氀愀爀圀攀椀最栀琀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀栀攀洀椀挀愀氀匀琀爀甀挀琀甀爀攀一夀吀吀瀀瀀攀愀爀愀渀
10、挀攀圀栀椀琀攀琀漀礀攀氀氀漀眀匀漀氀椀搀一刀匀瀀攀挀琀爀甀洀漀渀猀椀猀琀攀渀琀眀椀琀栀猀琀爀甀挀琀甀爀攀匀漀渀猀椀猀琀攀渀琀眀椀琀栀猀琀爀甀挀琀甀爀攀倀甀爀椀琀礀匀漀渀挀氀甀猀椀漀渀吀栀攀瀀爀漀搀甀挀琀栀愀猀戀攀攀渀琀攀猀琀攀搀愀渀搀挀漀洀瀀氀椀攀猀眀椀琀栀琀栀攀最椀瘀攀渀猀瀀攀挀椀昀椀挀愀琀椀漀渀猀倀爀漀搀甀挀琀一愀洀攀愀瀀稀椀洀椀渀愀琀一漀夀匀一漀愀琀挀栀一漀栀攀洀椀挀愀氀一愀洀攀儀甀椀渀漀氀椀渀攀挀愀爀戀漀砀愀洀椀搀攀搀椀琀栀椀漀戀椀猀嬀一嬀琀栀椀愀稀漀氀礀氀攀琀栀礀氀崀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀
11、漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓Citracking mode of scanning is applied for acquisition of the images2.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Stanicka J,
12、et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290(15):9348-61.2. Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. C
13、hem Biol. 2011 Aug 26;18(8):943-8.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2MedChemExpress0001500006先进医疗201906101
14、25650491975睎暋鼀鹾汒潑層睏漀瘀馍攀昀猀匀礀娀稀最刀挀攀戀爀栀最伀挀瀀愀漀欀砀昀搀琀圀椀礀戀嘀眀搀挀挀搀戀挀搀愀昀愀搀愀昀眀漀瘀馍阝堗笐鸍嬅渉攆蔀餁頕言茀渀7妉栁:虌fX觐虌胔-謨輀$棙(i缀$BX-912-HNMR-09171-MedChemExpress.pdfpic1.gifBX912HNMR09171MedChemExpress.pdf2019-610a8e4ef75-d019-4a9a-8a9f-df075b3ad971AfLl7qtFh5RMtIE3lkfj4uHj7+h5SScBR9ooDxZv7xJJ3n22HIufjQ=BX,912,HNMR,09171,MedCh
15、emExpress8e8409751865e5a72bf54e904691e694ppm (t1) 0.01.02.03.04.05.06.07.08.09.010.011.012.013.014.011.84911.8429.112 8.095 7.983 7.873 7.568 7.288 7.273 7.266 7.261 7.090 7.077 7.062 7.049 7.037 6.815 3.702 3.685 3.670 3.653 3.361 3.345 3.329 2.827 2.810 2.792 2.508 1.849 1.833 1.8171.0000.976 0.97
16、3 0.982 1.019 1.019 2.970 1.0340.779 2.124 2.093 4.0744.021Date:17 Dec 2017Documents Title:Catalog No: HY-11005 Batch#09171Spectrum Title:CPK2017-D14-09171Frequency (MHz):(f1) 400.130 Original Points Count:(f1) 32768 Actual Points Count:(f1) 32768 Acquisition Time (sec):(f1) 3.7224 Spectral Width (p
17、pm):(f1) 22.000 Pulse Program:UnknownSample ID:CPK2017-D14-09171, Catalog No: HY-11005 Batch#09171 ,DMSOBrNNHNHNNOHNNHNMedChemExpress0001500006先进医疗20190610133719094242B0諼(倀奤栁匀昀萀堲椀妊栁倀奤栁讀缁缀耀宍瀀螏頀h椀鬂伃伃伃較椋椋椋椋椋椋椋椋椋椋椋椋椋紀(娋栁搀堽椀娬栁娋栁讀缁実瀀螏頀h頀椀鬂贃愀瀀稀椀洀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀瀀稀椀洀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀
18、搀挀搀挀搀挀挀戀昀愀愀最娀樀眀砀焀攀一娀伀刀圀椀渀欀洀昀刀琀圀洀猀瀀瘀栀渀猀洀夀唀爀圀眀愀瀀稀椀洀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀挀攀挀愀戀攀攀攀攀愀愀愀瀀稀椀洀椀渀愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀茀耠舀萠丠蘀传舀匠萀漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀倀爀漀琀攀愀猀漀洀攀倀愀琀栀眀愀礀攀琀愀戀漀氀椀挀渀稀礀洀攀倀爀漀琀攀愀猀攀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀愀渀搀戀爀攀愀猀琀挀愀渀挀攀爀洀洀甀渀漀戀氀漀琀琀椀渀最昀漀爀琀栀攀瀀爀漀挀攀猀猀攀搀昀漀爀洀漀昀挀愀猀瀀愀猀攀愀渀搀挀愀猀瀀愀猀攀挀氀攀愀瘀攀搀
19、瀀漀氀礀倀爀椀戀漀猀攀瀀漀氀礀洀攀爀愀猀攀椀渀吀挀攀氀氀猀挀漀渀昀椀爀洀琀栀愀琀愀瀀稀椀洀椀渀渀漀琀漀渀氀礀戀氀漀挀欀猀挀攀氀氀最爀漀眀琀栀戀甀琀愀氀猀漀椀渀搀甀挀攀猀愀瀀漀瀀琀漀猀椀猀嬀崀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀倀刀伀吀伀伀椀渀愀猀攀猀猀愀礀嬀崀氀甀漀爀攀猀挀攀渀挀攀瀀漀氀愀爀椀稀愀琀椀漀渀愀猀猀愀礀猀愀爀攀瀀攀爀昀漀爀洀攀搀椀渀氀漀眀瘀漀氀甀洀攀眀攀氀氀猀漀氀椀搀戀氀愀挀欀瀀氀愀琀攀猀椀渀焀甀愀搀爀甀瀀氀椀挀愀琀攀吀栀攀愀猀猀愀礀猀愀爀攀瀀攀爀昀漀爀洀攀搀椀渀戀甀昀昀攀爀挀漀渀琀愀椀渀
20、椀渀最洀吀爀椀猀氀瀀洀最氀吀倀洀吀吀愀渀搀一倀吀栀攀挀漀洀瀀漀渀攀渀琀猀昀漀爀琀栀攀愀猀猀愀礀愀爀攀愀搀搀攀搀椀渀琀栀攀昀漀氀氀漀眀猀攀焀甀攀渀挀攀挀漀洀瀀漀甀渀搀愀瀀稀椀洀椀渀攀琀愀氀椀渀匀伀愀琀搀椀昀昀攀爀攀渀琀挀漀渀挀攀渀琀爀愀琀椀漀渀猀漀昀搀椀氀甀琀攀搀栀甀洀愀渀匀瀀爀漀琀攀愀猀漀洀攀愀渀搀漀昀猀甀戀猀琀爀愀琀攀渀唀戀瀀攀瀀琀椀搀攀伀娀渀挀礀挀氀攀渀椀猀瀀爀攀猀攀渀琀椀渀琀栀攀琀椀琀爀愀琀椀漀渀爀攀愀挀琀椀漀渀昀漀爀琀栀攀攀砀瀀攀爀椀洀攀渀琀猀瀀攀爀昀漀爀洀攀搀眀椀琀栀娀渀挀礀挀氀攀渀氀甀漀爀攀猀挀攀渀挀攀瀀漀氀愀爀椀稀愀琀椀漀渀椀猀洀攀愀猀甀爀攀搀愀琀眀椀琀栀攀砀挀椀琀愀琀椀漀渀愀琀
21、渀洀愀渀搀攀洀椀猀猀椀漀渀愀琀渀洀漀氀氀攀挀琀攀搀搀愀琀愀椀猀渀漀爀洀愀氀椀稀攀搀琀漀匀伀挀漀渀琀爀漀氀愀渀搀昀椀琀琀攀搀琀漀愀搀漀猀攀爀攀猀瀀漀渀猀攀挀甀爀瘀攀琀漀搀攀琀攀爀洀椀渀攀琀栀攀瘀愀氀甀攀嬀崀栀愀猀渀漀琀椀渀搀攀瀀攀渀搀攀渀琀氀礀挀漀渀昀椀爀洀攀搀琀栀攀愀挀挀甀爀愀挀礀漀昀琀栀攀猀攀洀攀琀栀漀搀猀吀栀攀礀愀爀攀昀漀爀爀攀昀攀爀攀渀挀攀漀渀氀礀攀氀氀猀猀愀礀嬀崀吀挀攀氀氀猀愀爀攀琀爀攀愀琀攀搀眀椀琀栀搀椀昀昀攀爀攀渀琀挀漀渀挀攀渀琀爀愀琀椀漀渀猀漀昀漀爀愀瀀稀椀洀椀渀昀漀爀栀漀甀爀猀椀渀渀漀爀洀愀氀漀爀氀漀眀猀攀爀甀洀洀攀搀椀甀洀愀渀搀琀栀攀渀洀椀砀攀搀眀椀琀栀攀氀氀吀椀琀攀爀氀漀爀
22、攀愀最攀渀琀琀漀攀猀琀椀洀愀琀攀挀攀氀氀瀀爀漀氀椀昀攀爀愀琀椀漀渀攀愀猀甀爀攀搀氀甀洀椀渀攀猀挀攀渀挀攀瘀愀氀甀攀猀愀爀攀渀漀爀洀愀氀椀稀攀搀琀漀匀伀挀漀渀琀爀漀氀愀渀搀搀愀琀愀愀爀攀昀椀琀琀攀搀琀漀愀搀漀猀攀爀攀猀瀀漀渀猀攀攀焀甀愀琀椀漀渀琀漀搀攀琀攀爀洀椀渀攀琀栀攀嬀崀栀愀猀渀漀琀椀渀搀攀瀀攀渀搀攀渀琀氀礀挀漀渀昀椀爀洀攀搀琀栀攀愀挀挀甀爀愀挀礀漀昀琀栀攀猀攀洀攀琀栀漀搀猀吀栀攀礀愀爀攀昀漀爀爀攀昀攀爀攀渀挀攀漀渀氀礀刀刀一匀嬀崀椀攀琀愀氀愀瀀稀椀洀椀渀椀猀愀瀀漀琀攀渀琀愀渀搀猀瀀攀挀椀昀椀挀椀渀栀椀戀椀琀漀爀漀昀瀀爀漀琀攀愀猀漀洀攀椀猀漀瀀攀瀀琀椀搀愀猀攀刀瀀渀一愀琀栀攀洀椀漀氀愀礀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀
