1、附(省搀%梴省冖省省讀缁缀耀螏頀h椀笂焃焏焏贏攀猀瀀攀爀愀搀椀渀甀爀漀爀愀椀渀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀攀猀瀀攀爀愀搀椀渀甀爀漀爀愀椀渀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀搀挀攀攀愀戀昀愀挀搀搀倀琀渀瀀攀堀倀匀椀瘀栀礀椀欀伀戀伀刀樀爀昀焀儀瀀洀漀洀搀爀最渀挀娀栀洀甀欀戀爀眀攀猀瀀攀爀愀搀椀渀甀爀漀爀愀椀渀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀昀攀愀戀戀搀昀搀昀攀昀攀昀昀戀攀攀猀瀀攀爀愀搀椀渀愀琀一漀夀匀一漀舀褠茀舠丠萀传茀匠尀摏瘯甀爀漀爀愀椀渀愀猀攀甀琀漀瀀栀愀最礀尀摏攀氀氀礀挀氀攀一愀洀愀最攀瀀椀最攀渀攀琀椀挀猀甀琀漀瀀栀愀最礀塐
2、倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀灠湥卣鹙豛匀伀攀洀最洀洀攠洀攀愀渀猀猀漀氀甀戀氀攀戀甀琀猀愀琀甀爀愀琀椀漀渀甀渀欀渀漀眀渀漀渀挀攀渀琀爀愀琀椀漀渀匀漀氀瘀攀渀琀愀猀猀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐卭蕏鹑豛鶋轏匀伀最琀最琀挀漀爀渀漀椀氀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀倀最琀最琀吀眀攀攀渀最琀最琀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀伀伀吀嘀吀夀挀椯攀猀瀀攀爀愀搀椀渀吀倀襺譎著腶癯愀甀爀漀爀愀鄀渀蔀耠嬀崀甀夀攀琀愀氀栀攀洀椀挀愀氀攀渀漀洀椀挀猀瀀瀀爀漀愀挀栀攀愀搀猀琀漀琀栀攀搀攀渀琀
3、椀昀椀挀愀琀椀漀渀漀昀攀猀瀀攀爀愀搀椀渀愀渀甀爀漀爀愀椀渀愀猀攀渀栀椀戀椀琀漀爀愀猀愀爀漀愀搀匀瀀攀挀琀爀甀洀渀昀氀甀攀渀稀愀渀琀椀瘀椀爀愀氀渀琀漀氀匀挀椀匀攀瀀嬀崀愀搀礀最椀渀愀一攀琀愀氀昀昀攀挀琀漀昀琀栀攀瀀栀愀爀洀愀挀漀氀漀最椀挀愀氀愀最攀渀琀栀攀猀瀀攀爀愀搀椀渀漀渀戀爀攀愀猀琀愀渀搀瀀爀漀猀琀愀琀攀琀甀洀漀爀挀甀氀琀甀爀攀搀挀攀氀氀猀椀漀洀攀搀栀椀洀愀爀瀀爀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀
4、爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓愁言茀渀7瀀冗省:Q靰胔-)輀0棙i缀$His-Pro-hydrochloride-Peptide-MedChemExpress.pdfpic1.gifHisProhydrochloridePeptideMedChemExpress.pdf2019-62589460ac6-4047-472d-b12c-7d8fa8338933ev5ub1759JLcugNA7GecryECWd0DMu/FooqoFyJ/xE52wtKD8Xz/XQ=His,Pro,hydrochloride,Peptide,MedC
5、hemExpress3b4c85e81da6852667705535c9165152His-Pro hydrochlorideCat. No.: HY-111659A分式: CHClNO分量: 288.73作靶点: Others作通路: Others储存式: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITY物活性 His-Pro hydrochloride 是种由组氨酰和脯氨酸组成的肽 。REFERENCES1. Park SW, et al. Alterations
6、 in pancreatic protein expression in STZ-induced diabetic rats and genetically diabetic mice in response to treatment with hypoglycemic dipeptide Cyclo (His-Pro). Cell Physiol Biochem. 2012;29(3-4):603-16.McePdfHeightCaution: Product has not been fully validated for medical applications. For researc
7、h use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师Product Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1MedChemExpress0001500006先进医疗20190625152357155333Hansplantation in nude mice. When tumors have reached a volume of app
8、r 50 to 100 mm3, animals are randomized into treatment and control groups of 10 mice each. Volasertib is formulated in hydrochloric acid (0.1 N), diluted with 0.9% NaCl, and injected i.v. into the tail vein at the indicated dose and schedule. For oral treatment, Volasertib is resuspended in 0.5% Nat
9、rosol 250 hydroxyethyl-cellulose and given intragastrally via gavage needle. An administration volume of 10 mL per kilogram of body weight is used for both administration routes. Tumor volumes are determined thrice a week using a caliper. The results are converted to tumor volume 靰(省搀翽瞠梸省瀂冗省省讀缁缀耀螏頀h
10、椀贂礃椀猀倀爀漀倀攀瀀琀椀搀攀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀椀猀倀爀漀倀攀瀀琀椀搀攀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀挀戀昀昀攀戀愀搀愀愀氀渀氀瘀吀琀攀砀礀吀琀猀堀嘀昀栀栀瀀樀倀稀昀嘀圀夀椀儀倀砀琀瀀儀椀猀倀爀漀倀攀瀀琀椀搀攀攀搀栀攀洀砀瀀爀攀猀猀挀愀攀愀挀挀戀搀愀搀昀戀愀攀挀椀猀倀爀漀愀琀一漀夀匀一漀脀脠脀蘠丠萀传茀尀摏瘯伀琀栀攀爀猀尀摏伀琀栀攀爀猀塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯椀猀倀爀漀f灬貑硬葢到刀一匀嬀崀倀愀爀欀匀圀攀琀愀氀氀琀攀爀愀琀椀漀渀猀椀渀瀀愀渀挀爀攀愀琀椀挀瀀爀漀琀攀
11、椀渀攀砀瀀爀攀猀猀椀漀渀椀渀匀吀娀椀渀搀甀挀攀搀搀椀愀戀攀琀椀挀爀愀琀猀愀渀搀最攀渀攀琀椀挀愀氀氀礀搀椀愀戀攀琀椀挀洀椀挀攀椀渀爀攀猀瀀漀渀猀攀琀漀琀爀攀愀琀洀攀渀琀眀椀琀栀栀礀瀀漀最氀礀挀攀洀椀挀搀椀瀀攀瀀琀椀搀攀礀挀氀漀椀猀倀爀漀攀氀氀倀栀礀猀椀漀氀椀漀挀栀攀洀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶偞爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠
12、挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓持言茀渀7鰀冘省礈:鄀颜胔-)輀棙i缀$HMN-176-MedChemExpress.pdfpic1.gifHMN176MedChemExpress.pdf2019-6253f79045c-24b2-4f1f-b5f7-1c980d1071c74VyyBW4TuXpdfXc0VWcxydcf6SKwAZlrMEflW+Jmda00sZ0c9nogg=HMN,176,MedChemExpressbfee23691cb1bed116b470198e6e588fHMN-176Cat. No.: HY-13647C
13、AS No.: 173529-10-7分式: CHNOS分量: 382.43作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 30 mg/mL (78.45 mM)* “ means soluble, but saturation unknown.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 2.6149 mL 13.0743 mL 26.1486 mL5 mM 0.5230 mL
14、2.6149 mL 5.2297 mL制备储备液10 mM 0.2615 mL 1.3074 mL 2.6149 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液BIOLOGICAL ACTIVITY物活性 HMN-176 是苯基烯的衍物，能够抑制有丝分裂，扰 plk1，但对微管蛋的聚合影响不 。IC 8(3):592-601.2. Medina-Gundrum L, et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN
15、-176 on differential gene expression. Invest New Drugs. 2005 Jan;23(1):3-9.3. Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-9
16、9.4. Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7.5. Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a n
17、ovel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE2MedChemExpress0001500006先进医疗20190625152357686358HD最搀栀琀洀氀舀炲/Ke前台访问/d-136233.html123.125.71.190緊0D愀瀀栀琀洀氀瀁搞/Kg前台访问/p-177106.html123.125.71.1150緌0D攀瀀
