1、(礀搀瘀凅礁礀礀讀缁缀怀茀螏頀h椀鴂椂嘍漀爀攀氀漀砀椀渀匀一匀吀漀瀀漀椀猀漀洀攀爀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀嘀漀爀攀氀漀砀椀渀匀一匀吀漀瀀漀椀猀漀洀攀爀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀攀愀挀攀愀挀搀搀愀愀昀挀挀攀愀戀昀倀一瘀砀最欀漀最攀洀吀欀倀嘀眀瀀瀀愀娀最栀欀椀洀吀愀椀一唀儀嘀漀爀攀氀漀砀椀渀匀一匀吀漀瀀漀椀猀漀洀攀爀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀搀挀戀戀挀昀愀愀搀搀嘀漀爀攀氀漀砀椀渀愀琀一漀夀匀一漀脀蠠脀褠丠蔀传萀匠尀摏瘯吀漀瀀漀椀猀漀洀攀爀愀猀攀尀摏攀氀氀礀挀氀攀一愀洀愀最攀塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀
2、挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯嘀漀爀攀氀漀砀椀渀f葒兢葟癧琀漀瀀漀椀猀漀洀攀爀愀猀攀鄀一蔀耠嬀崀匀挀愀琀攀渀愀攀琀愀氀嘀漀爀攀氀漀砀椀渀愀昀椀爀猀琀椀渀挀氀愀猀猀愀渀琀椀挀愀渀挀攀爀焀甀椀渀漀氀漀渀攀搀攀爀椀瘀愀琀椀瘀攀愀挀琀猀猀礀渀攀爀最椀猀琀椀挀愀氀氀礀眀椀琀栀挀礀琀愀爀愀戀椀渀攀椀渀瘀椀琀爀漀愀渀搀椀渀搀甀挀攀猀戀漀渀攀洀愀爀爀漀眀愀瀀氀愀猀椀愀椀渀瘀椀瘀漀愀渀挀攀爀栀攀洀漀琀栀攀爀倀栀愀爀洀愀挀漀氀伀挀琀嬀崀圀愀氀猀戀礀攀琀愀氀吀栀攀琀漀瀀漀椀猀漀洀攀爀愀猀攀椀渀栀椀戀椀琀漀爀瘀漀爀攀氀漀砀椀渀挀愀甀猀攀猀挀攀氀氀挀礀挀氀攀愀
3、爀爀攀猀琀愀渀搀愀瀀漀瀀琀漀猀椀猀椀渀洀礀攀氀漀椀搀氀攀甀欀攀洀椀愀挀攀氀氀猀愀渀搀愀挀琀猀椀渀猀礀渀攀爀最礀眀椀琀栀挀礀琀愀爀愀戀椀渀攀愀攀洀愀琀漀氀漀最椀挀愀愀爀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶爀甀最攀猀攀瘀攀氀吀栀攀爀瀀爀伀渀挀漀琀愀爀最攀琀愀爀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓嘀封言茀渀7礀崍:v胔-輀,棙i缀$VX-702-p3
4、8-MAPK-Inhibitor-MedChemExpress.pdfpic1.gifVX702p38MAPKInhibitorMedChemExpress.pdf2019-62627360153-eecf-403f-aab6-c889aa6fcd98OWe39CEzxIVRftjYnbuCoT5Jm/hEZZsz+y+6DsA1Xce/Qe/8ECn3Ow=VX,702,p38,MAPK,Inhibitor,MedChemExpressfe7bbcbba02000b23dd192dfc5e4eefeVX-702Cat. No.: HY-10401CAS No.: 745833-23-2分式:
5、 CHFNO分量: 404.32作靶点: p38 MAPK作通路: MAPK/ERK Pathway储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 42 mg/mL (103.88 mM)* “ means soluble, but saturation unknown.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 2.4733 mL 12.3664 mL 24.7329 mL5 mM 0.4947 mL 2.4733 mL
6、 4.9466 mL制备储备液10 mM 0.2473 mL 1.2366 mL 2.4733 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液体内实验 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.18 mM); Clear solution1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.18 mM); Clear solution2. BIOLOGICAL ACTIVITY物活性 VX-702是 p
7、38MAPK选择性抑制剂， IC50为4到20 nM。客户使本产品发表的科研献Product Data Sheet InhibitorsAgonistsScreening Libraries Harvard Medical School LINCS LIBRARYwww.MedChemE1See more customer validations on www.MedChemEREFERENCES1. Kuliopulos A, et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet agg
8、regation. Thromb Haemost, 2004, 92(6), 1387-1393.2. Braddock M, IDDB Meeting Report, 2005, March 14-15.3. Gill A, IDDB Meeing Report, 2002, March 06-08.4. Naka K, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015 Aug 20;
9、6:8039.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE2MedChemExpress0001500006先进医疗20190626101421366351V(倀礀搀嘀凈礁礀倀礀讀缁缀茀螏頀h椀笂國夀吀
10、刀攀挀攀瀀琀漀爀渀琀愀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀圀夀吀刀攀挀攀瀀琀漀爀渀琀愀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀攀挀愀昀攀昀攀戀愀攀挀攀氀琀攀昀欀娀欀樀砀戀唀倀最焀圀一琀伀爀刀刀昀欀娀刀礀匀嘀最昀嘀刀眀圀夀吀刀攀挀攀瀀琀漀爀渀琀愀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀搀愀搀昀昀愀挀挀愀搀戀攀挀戀圀夀愀琀一漀夀匀一漀舀蔠茀萠丠萀传舀尀摏瘯吀刀攀挀攀瀀琀漀爀尀摏倀刀倀爀漀琀攀椀渀一攀甀爀漀渀愀氀匀椀最渀愀氀椀渀最塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯圀夀吀葥酠盿瀀瀀蔀耠嬀崀漀
11、爀渀愀氀攀琀愀氀圀夀愀瀀漀琀攀渀琀愀渀搀猀攀氀攀挀琀椀瘀攀栀礀搀爀漀砀礀琀爀礀瀀琀愀洀椀渀攀愀渀琀愀最漀渀椀猀琀椀渀挀爀攀愀猀攀猀猀攀爀漀琀漀渀攀爀最椀挀渀攀甀爀漀渀愀氀愀挀琀椀瘀椀琀礀椀渀戀攀栀愀瘀椀渀最挀愀琀猀挀漀洀瀀愀爀椀猀漀渀眀椀琀栀匀圀夀倀栀愀爀洀愀挀漀氀砀瀀吀栀攀爀甀最挀攀倀搀昀攀椀最栀琀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀
12、琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓圀币言茀渀7礀劳:V胔-輀=棙i缀$WAY-100635-Maleate-5-HT-Receptor-Inhibitor-MedChemExpress.pdfpic1.gifWAY100635Maleate5HTReceptorInhibitorMedChemExpress.pdf2019-62640ee6e16-84e8-497a-840a-94ca38d9a550xGfjuiQYy+icFlxSsSowdkgB452BtXOIGsoNdS0Gt7m+qTA
13、AcQpP9w=WAY,100635,Maleate,HT,Receptor,Inhibitor,MedChemExpress08257068856573b26586abd774a0cec8WAY-100635 MaleateCat. No.: HY-10349ACAS No.: 1092679-51-0分式: CHNO分量: 538.64作靶点: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解
14、性数据体外实验 DMSO : 250 mg/mL (464.13 mM)H2O : 25 mg/mL (46.41 mM; Need ultrasonic)* “ means soluble, but saturation unknown.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 1.8565 mL 9.2826 mL 18.5653 mL5 mM 0.3713 mL 1.8565 mL 3.7131 mL制备储备液10 mM 0.1857 mL 0.9283 mL 1.8565 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液BI
15、OLOGICAL ACTIVITY物活性 WAY-100635 Maleate 是有效的，5- HT1A 的选择性抑制剂，其 pIC50值为 8.87， pA2 值为 9.71 。IC 281(1):81-8.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Mol
16、ecules 您边的抑制剂师www.MedChemE2MedChemExpress0001500006先进医疗20190626101422101348W栀tta-q6-calcium-channel-antagonist-medchemexpress.pd鎂虐價琀礀爀漀猀椀渀攀牁蜃蚓價腐言tyrosin鎂虐價琀礀爀漀猀椀渀攀欀椀渀愀猀攀椀渀栀椀戀椀琀漀爀挀洀攀琀栀最昀爀椀渀栀椀戀椀琀漀爀洀攀搀挀栀攀洀攀砀瀀爀攀猀猀瀀搀牁ua艡蚓凹腑騀牁ua蝡蚓凹腑騀牁舃蚓凹腑騀uaa-crosslinker-2-medchemexpress.pd鎂虒勹甀戀挀栀挀牁蜃蚓勹腒ubch5鎂虒勹p甀戀挀栀挀椀渀攀攀攀
17、攀渀稀礀洀攀椀渀栀椀戀椀琀漀爀洀攀搀挀栀攀洀攀砀瀀爀攀猀猀瀀搀昀舅蚓嗹荓vandetanib!蜅蚓嗹荓vandetanib!牁舃蚓囹腖vaniprevi鎇虖囹瘀愀渀椀瀀爀攀瘀椀爀牁舃蚓培腗varlitini鎇虗培瘀愀爀氀椀琀椀渀椀戀舅蚓嗹荓偐vegfr!蜅蚓嗹荓vegfr!舅蚓嗹荓偐儀vegfr-inhibitor-medchemexpress.pdf!牁舃蚓壹腘謀vimirogan鎇虘壹瘀椀洀椀爀漀最愀渀琀牁舃蚓姹腙鬀vismodegi鎇虙姹瘀椀猀洀漀搀攀最椀戀牁舃蚓嫹腚vorasideni鎇虚嫹瘀漀爀愀猀椀搀攀渀椀戀牁舃蚓对腛voreloxi鎇虛对瘀漀爀攀氀漀砀椀渀牁vt艰蚓壹腘謀牁vt蝰
18、蚓壹腘謀牁v艸蚓峹腜牁v蝸蚓峹腜(礀搀萀%凌礁氂礀礀讀缁缀鐀茀螏頀h椀猃圔刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀瀀瀀挀琀椀瘀愀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀圀刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀瀀瀀挀琀椀瘀愀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀挀戀挀挀攀愀愀挀洀樀礀渀愀夀稀攀猀稀攀愀堀娀漀猀昀堀圀匀漀渀眀娀吀欀吀唀甀圀琀一眀圀刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀瀀挀琀椀瘀愀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀戀戀攀愀愀挀戀挀攀愀圀刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀愀琀一漀夀匀一漀蔀脀蘠氀舀丠舀匠尀摏瘯瀀尀摏瀀漀瀀琀漀猀椀猀塐倀漀眀搀攀爀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀灠湥卣鹙豛匀伀洀
19、最洀洀一攀攀搀甀氀琀爀愀猀漀渀椀挀漀渀挀攀渀琀爀愀琀椀漀渀匀漀氀瘀攀渀琀愀猀猀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐伀伀吀嘀吀夀挀椯圀刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀换魧潵榃葲屠摏盿一鴀噏瀀蔀耠匀栀愀洀漀瀀攀爀愀琀攀搀最爀漀甀瀀椀猀猀甀戀樀攀挀琀攀搀漀渀氀礀琀漀猀甀爀最椀挀愀氀瀀爀漀挀攀搀甀爀攀嘀攀栀椀挀氀攀猀愀氀椀渀攀琀爀攀愀琀攀搀最爀漀甀瀀爀攀挀攀椀瘀攀猀猀愀氀椀渀攀椀渀琀爀愀匀一挀攀猀椀漀渀攀搀最爀漀甀瀀爀攀挀攀椀瘀攀猀栀礀搀爀漀砀礀搀漀瀀愀洀椀渀攀嘀攀栀椀挀氀攀伀最爀漀甀瀀爀攀挀攀椀瘀攀猀猀愀氀椀渀攀愀猀愀瘀攀栀椀挀氀攀搀愀礀猀漀渀挀攀搀愀椀氀礀爀愀琀戀攀昀漀爀攀伀椀渀樀攀挀琀椀漀
20、渀琀漀刀愀琀猀椀渀琀栀攀猀攀最爀漀甀瀀猀愀爀攀瀀爀攀琀爀攀愀琀攀搀眀椀琀栀椀渀琀爀愀匀一挀椀渀樀攀挀琀椀漀渀漀昀圀刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀圀刀愀渀搀會爀愀琀搀愀礀猀戀攀昀漀爀攀伀椀渀樀攀挀琀椀漀渀一漀渀氀攀猀椀漀渀攀搀愀渀椀洀愀氀猀爀攀挀攀椀瘀攀椀渀琀爀愀匀一挀椀渀樀攀挀琀椀漀渀漀昀圀刀搀椀栀礀搀爀漀挀栀氀漀爀椀搀攀會爀愀琀昀漀爀琀栀爀攀攀搀愀礀猀嬀崀栀愀猀渀漀琀椀渀搀攀瀀攀渀搀攀渀琀氀礀挀漀渀昀椀爀洀攀搀琀栀攀愀挀挀甀爀愀挀礀漀昀琀栀攀猀攀洀攀琀栀漀搀猀吀栀攀礀愀爀攀昀漀爀爀攀昀攀爀攀渀挀攀漀渀氀礀刀刀一匀嬀崀倀氀甀焀甀攀琀伀攀琀愀氀吀栀攀挀礀琀漀瀀爀漀琀攀挀琀椀瘀攀愀洀椀渀漀琀栀椀
21、漀氀圀刀愀挀琀椀瘀愀琀攀猀瀀琀栀爀漀甀最栀愀渀漀渀最攀渀漀琀漀砀椀挀猀椀最渀愀氀椀渀最瀀愀琀栀眀愀礀椀渀瘀漀氀瘀椀渀最挀甀渀一琀攀爀洀椀渀愀氀欀椀渀愀猀攀椀漀氀栀攀洀瀀爀嬀崀匀栀攀渀攀琀愀氀椀渀搀椀渀最漀昀琀栀攀愀洀椀渀漀琀栀椀漀氀圀刀琀漀琀爀愀渀猀挀爀椀瀀琀椀漀渀昀愀挀琀漀爀猀椀渀昀氀甀攀渀挀攀猀挀攀氀氀甀氀愀爀爀攀猀瀀漀渀猀攀琀漀愀渀琀椀挀愀渀挀攀爀搀爀甀最猀倀栀愀爀洀愀挀漀氀砀瀀吀栀攀爀甀渀嬀崀昀猀栀椀渀栀攀爀愀搀洀愀渀搀攀琀愀氀昀昀攀挀琀漀昀圀刀漀渀栀礀搀爀漀砀礀搀漀瀀愀洀椀渀攀椀渀搀甀挀攀搀挀愀琀愀氀攀瀀猀礀愀渀搀氀攀瘀攀氀椀渀爀愀琀猀爀愀渀愀猀椀挀攀搀匀挀椀愀礀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓圀态言茀渀7頀礀:胔-輀棙i缀$WZ4141-MedChem
