1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBafilomycin A1Cat. No.: HY-100558CAS No.: 88899-55-2Synonyms: (-)-Bafilomycin A1分式: CHO分量: 622.83作靶点: Proton Pump; Autophagy作通路: Membrane Transporter/Ion Channel; Autophagy储存式: Powder -20C 3 years-80C 6 monthsIn solvent-20C 1 mo
2、nth溶解性数据体外实验 DMSO : 100 mg/mL (160.56 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.01 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.01 mM); Suspended solution; Need ultrasonic3. 请依序添加每种溶剂： 10% DMSO 90% corn oil体内实验
3、1/3 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (4.01 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Bafilomycin A1， 种从链霉菌属物种中分离的环内酯类抗素，是特异的 vacuolar-type H+ ATPase (V-ATPase) 抑制剂。 Bafilomycin A1 抑制噬 1。IC50 15(6):1017-1030.2/3 Master of Small Molecules 您边的抑制剂师www.MedChemE Autophagy
4、. 2019 Mar 25:1-17. Theranostics. 2019 Jul 9;9(17):4878-4892. Theranostics 2018; 8(19):5434-5451. See more customer validations on www.MedChemEREFERENCES1. Yuan N, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 201
5、5 Mar;100(3):345-56.2. Lu X, et al. Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression. Exp Ther Med. 2015 Nov;10(5):1829-1834.3. Ohkuma S, et al. Inhibition of cell growt
6、h by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase. In Vitro Cell Dev Biol Anim. 1993 Nov;29A(11):862-6.4. Ohta T, et al. Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1. J Pathol. 1998 Jul;185(3):324-30.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE3/3 Master of Small Molecules 您边的抑制剂师
