1、分子量283.25 溶解性(25C) DMSO 分子式C H FNOWater CAS号154554-41-3Ethanol 储存条件3年 -20C 粉末状 生物活性 CHM 1 is a inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G /M phase by activation of Cdc2
2、 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells. 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南) 小鼠大鼠兔豚鼠仓鼠狗 重量 (
3、kg)0.020.151.80.40.0810 体表面积 (m )0.0070.0250.150.050.020.5 K 系数36128520 动物 A (mg/kg) = 动物 B (mg/kg) 动物 B的K 系数 动物 A的K 系数 例如,依据体表面积折算法,将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量,需要将22.4 mg/kg 乘以小鼠的K 系数(3),再除以大鼠的K 系数(6), 得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。 参考文献 Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Nozaki, et al. Breast Cancer Res Treat. 2004;83: 195. PMID: 14758089. CHM 1 目录号M6597 化学数据 16103 2 2 m m m mm