1、Levomefolic acidCat. No.: HY-14781CAS No.: 31690-09-2Molecular Formula: CHNOMolecular Weight: 459.46Target: AntifolatePathway: Cell Cycle/DNA DamageStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent Need ultrasonic)DMSO : 0.526 mg/mL (1.14 mM; Need ultrasonic and warmi
2、ng)ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 2.1765 mL 10.8823 mL 21.7647 mL5 mM 0.4353 mL 2.1765 mL 4.3529 mLPreparing Stock Solutions10 mM 0.2176 mL 1.0882 mL 2.1765 mLPlease refer to the solubility information to select the appropriate solvent.BIOLOGICAL ACTIVITYDescription Levomefolic acid (
3、5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analogLevomefolic acid has been proposed for treatment of cardiovascular disease and advanced can
4、cers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro.REFERENCES1. Hirsch S, Miranda D, Mu?oz E, et al. Natural killer cell cytotoxicity is not re
5、gulated by folic acid in vitro. Nutrition. 2013 Jan 9. pii: S0899-9007(12)00404-2.2. Liu Y, Green TJ, Wong P, Kitts DD. Microencapsulation of L-5-methyltetrahydrofolic Acid with ascorbate improves stability in baked bread products. J Agric Food Chem. 2013 Jan 9;61(1):247-54.Product Data Sheet Inhibi
6、torsAgonistsScreening Librarieswww.MedChemE13. Merola N, Alonso FJ, Ros G, Castn MJ. Antioxidant activity comparison between 6S-5-methyltetrahydrofolic acid calcium salt and the related racemate form. Food Chem. 2013 Jan 15;136(2):984-8.4. Liu Y, Tomiuk S, Rozoy E, et al. Thermal oxidation studies o
7、n reduced folate, L-5-methyltetrahydrofolic acid (L-5-MTHF) and strategies for stabilization using food matrices. J Food Sci. 2012 Feb;77(2):C236-43.5. Bashir M Rezka, Guido R.M.M Haenena, Wim J.F van der Vijgha, et al. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant
8、activity. Identification of the antioxidant pharmacophore. 2003,555(3):601-605.6. Levomefolic acidCaution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2
