1、TolvaptanCat. No.: HY-17000CAS No.: 150683-30-0Molecular Formula: CHClNOMolecular Weight: 448.94Target: Vasopressin Receptor; AutophagyPathway: GPCR/G Protein; AutophagyStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent 69 Suppl 9:408-11.3. Vaduganathan M, Gheorghiade
2、M, Pang PS, Konstam MA, Zannad F, Swedberg K, Grinfeld L, Burnett JC Jr, Krasa HB, Zimmer C, Blair J, Ouyang J, Maggioni AP; EVEREST investigators.Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment.J Cardiovasc Med (Hagerstown). 2012 Jul;13(7):415-22.4.
3、Y Yamamura et al. OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats. J. Pharmacol. Exp. Ther. 1998, 287(3), 860-867.5. RW Schrier et al. Tolvaptan, a Selective Oral Vasopressin V2-Receptor Anta
4、gonist, for Hyponatremia. N Engl J Med 2006, 355, 2099-2112.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA FASEB J. 2018 Jul 23:fj201800436R.www.MedChemE2
