1、分子量271.59 溶解性(25C) DMSO 分子式C H Cl N S HClWater CAS号72214-67-6Ethanol 储存条件3年 -20C 粉末状 生物活性 RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional acti
2、vity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD- 251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 doe
3、s not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1. 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南) 小鼠大鼠兔豚鼠仓鼠狗 重量 (kg)0.020.151.80.40.0810 体表面积 (m )0.0070.0250.150.050.020.5 K 系数36128520 动物 A (mg/kg) = 动物 B (mg/kg) 动物 B的K 系数 动物 A的K 系数 例如,依据体表面积折算法,将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量,需要将22.4 mg/kg 乘以小鼠的K 系数(3),再除以大鼠的K 系数(6), 得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。 RRD-251 hydrochloride 目录号M8142 化学数据 8822 2 m m m mm