1、匀(币搀琀币币币讀缁缀渪漁螏頀h椀鼂匃匃匃錃嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜嬜崜甀昀漀琀愀氀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀甀昀漀琀愀氀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀愀搀戀搀愀戀挀搀昀攀愀栀夀伀嘀唀娀猀砀甀欀眀娀渀吀猀稀栀愀伀礀欀眀唀砀漀昀娀栀挀琀最甀昀漀琀愀氀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀攀戀昀攀愀攀搀攀戀搀甀昀漀琀愀氀椀渀愀琀一漀夀一匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀舀蘠茀蘠传蘀漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀伀琀栀攀爀猀倀愀琀栀眀愀礀伀琀栀攀爀猀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀
2、猀洀漀渀琀栀匀漀氀瘀攀渀琀愀渀漀瘀攀氀愀渀琀椀漀猀琀攀漀戀氀愀猀琀漀洀愀愀最攀渀琀瘀愀氀甀攀吀愀爀最攀琀椀渀瘀椀琀爀漀戀甀昀漀琀愀氀椀渀椀渀搀甀挀攀搀漀猀琀攀漀戀氀愀猀琀漀洀愀挀攀氀氀搀攀愀琀栀愀渀搀愀瀀漀瀀琀漀猀椀猀椀渀搀漀猀攀愀渀搀琀椀洀攀搀攀瀀攀渀搀攀渀琀洀愀渀渀攀爀猀甀爀琀栀攀爀戀甀昀漀琀愀氀椀渀椀渀搀甀挀攀搀攀渀搀漀瀀氀愀猀洀椀挀爀攀琀椀挀甀氀甀洀刀猀琀爀攀猀猀愀挀琀椀瘀愀琀椀漀渀椀渀漀猀琀攀漀戀氀愀猀琀漀洀愀挀攀氀氀猀琀栀攀氀愀琀琀攀爀眀愀猀搀攀琀攀挀琀攀搀戀礀琀栀攀椀渀搀甀挀琀椀漀渀漀昀倀栀漀洀漀氀漀最漀甀猀瀀爀漀琀攀椀渀伀倀瀀栀漀猀瀀栀漀爀礀氀愀琀椀漀渀漀昀椀渀漀猀椀琀漀氀爀攀
3、焀甀椀爀椀渀最攀渀稀礀洀攀刀愀渀搀倀刀氀椀欀攀攀渀搀漀瀀氀愀猀洀椀挀爀攀琀椀挀甀氀甀洀欀椀渀愀猀攀倀刀愀猀眀攀氀氀愀猀挀愀猀瀀愀猀攀愀挀琀椀瘀愀琀椀漀渀嬀崀甀昀漀琀愀氀椀渀眀愀猀琀栀攀洀漀猀琀瀀漀琀攀渀琀愀挀琀椀瘀攀挀漀洀瀀漀甀渀搀愀洀漀渀最琀栀攀猀攀昀漀甀爀戀甀昀愀搀椀攀渀漀氀椀搀攀猀愀渀搀椀琀攀砀攀爀琀攀搀猀琀爀漀渀最攀爀椀渀栀椀戀椀琀漀爀礀攀昀昀攀挀琀漀渀琀栀攀瘀椀愀戀椀氀椀琀礀漀昀搀漀砀漀爀甀戀椀挀椀渀椀渀搀甀挀攀搀洀甀氀琀椀搀爀甀最爀攀猀椀猀琀愀渀琀氀椀瘀攀爀挀愀渀挀攀爀挀攀氀氀猀刀攀瀀琀栀愀渀琀栀愀琀漀昀琀栀攀椀爀瀀愀爀攀渀琀挀攀氀氀猀攀瀀戀甀昀漀琀愀氀椀渀琀爀攀愀琀洀攀渀琀椀渀搀
4、甀挀攀搀挀攀氀氀挀礀挀氀攀愀爀爀攀猀琀愀琀瀀栀愀猀攀琀栀爀漀甀最栀搀漀眀渀爀攀最甀氀愀琀椀漀渀漀昀甀爀漀爀愀挀礀挀氀椀渀愀渀搀挀礀挀氀椀渀愀猀眀攀氀氀愀猀甀瀀爀攀最甀氀愀琀椀漀渀漀昀瀀愀渀搀瀀甀昀漀琀愀氀椀渀琀爀攀愀琀洀攀渀琀愀氀猀漀椀渀搀甀挀攀搀愀瀀漀瀀琀漀猀椀猀眀栀椀挀栀眀愀猀愀挀挀漀洀瀀愀渀椀攀搀戀礀搀攀挀爀攀愀猀攀椀渀洀椀琀漀挀栀漀渀搀爀椀愀氀洀攀洀戀爀愀渀攀瀀漀琀攀渀琀椀愀氀椀渀挀爀攀愀猀攀猀椀渀椀渀琀爀愀挀攀氀氀甀氀愀爀挀愀氀挀椀甀洀氀攀瘀攀氀愀渀搀爀攀愀挀琀椀瘀攀漀砀礀最攀渀猀瀀攀挀椀攀猀瀀爀漀搀甀挀琀椀漀渀愀挀琀椀瘀愀琀椀漀渀猀漀昀挀愀猀瀀愀猀攀愀渀搀挀氀攀愀瘀愀最攀漀昀瀀漀氀
5、礀倀爀椀戀漀猀攀瀀漀氀礀洀攀爀愀猀攀倀刀倀愀猀眀攀氀氀愀猀挀栀愀渀最攀猀椀渀琀栀攀攀砀瀀爀攀猀猀椀漀渀猀漀昀戀挀氀愀渀搀戀愀砀嬀崀甀昀漀琀愀氀椀渀瀀爀漀洀漀琀攀搀搀攀愀琀栀爀攀挀攀瀀琀漀爀洀攀搀椀愀琀攀搀挀攀氀氀搀攀愀琀栀攀猀瀀攀挀椀愀氀氀礀吀刀椀渀搀甀挀攀搀愀瀀漀瀀琀漀猀椀猀琀栀爀漀甀最栀愀挀琀椀瘀愀琀椀漀渀漀昀挀愀猀瀀愀猀攀攀猀挀爀椀瀀琀椀漀渀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀愀渀搀倀刀倀漀琀爀攀愀琀洀攀渀琀漀昀戀甀昀漀琀愀氀椀渀眀椀琀栀吀刀爀攀猀甀氀琀攀搀椀渀琀栀攀搀漀眀渀爀攀最甀氀愀琀椀漀渀
6、漀昀愀渀琀椀愀瀀漀瀀琀漀琀椀挀瀀爀漀琀攀椀渀猀椀渀挀氀甀搀椀渀最挀氀堀挀氀猀甀爀瘀椀瘀椀渀愀渀搀堀倀愀渀搀琀栀攀甀瀀爀攀最甀氀愀琀椀漀渀漀昀倀猀愀渀搀吀刀爀攀挀攀瀀琀漀爀刀渀愀搀搀椀琀椀漀渀瀀栀漀猀瀀栀漀爀礀氀愀琀椀漀渀漀昀匀吀吀眀愀猀猀琀爀漀渀最氀礀椀渀栀椀戀椀琀攀搀戀礀戀甀昀漀琀愀氀椀渀嬀崀攀砀琀攀爀渀愀氀椀稀愀琀椀漀渀漀昀瀀栀漀猀瀀栀愀琀椀搀礀氀猀攀爀椀渀攀愀挀挀甀洀甀氀愀琀椀漀渀漀昀猀甀戀挀攀氀氀猀昀爀愀最洀攀渀琀愀琀椀漀渀漀昀一愀渀搀昀漀爀洀愀琀椀漀渀漀昀愀瀀漀瀀琀漀琀椀挀戀漀搀椀攀猀眀攀爀攀漀戀猀攀爀瘀攀搀椀渀戀甀昀漀琀愀氀椀渀琀爀攀愀琀攀搀攀瀀挀攀氀氀猀嬀崀刀刀一匀嬀崀娀栀甀夀刀
7、攀琀愀氀甀昀漀琀愀氀椀渀椀渀搀甀挀攀搀愀瀀漀瀀琀漀猀椀猀椀渀漀猀琀攀漀戀氀愀猀琀漀洀愀挀攀氀氀猀椀猀愀猀猀漀挀椀愀琀攀搀眀椀琀栀攀渀搀漀瀀氀愀猀洀椀挀爀攀琀椀挀甀氀甀洀猀琀爀攀猀猀愀挀琀椀瘀愀琀椀漀渀椀漀挀栀攀洀椀漀瀀栀礀猀刀攀猀漀洀洀甀渀甀最嬀崀娀栀愀渀最攀琀愀氀甀昀漀琀愀氀椀渀昀爀漀洀嘀攀渀攀渀甀洀甀昀漀渀椀猀椀渀栀椀戀椀琀猀最爀漀眀琀栀漀昀洀甀氀琀椀搀爀甀最爀攀猀椀猀琀愀渀琀攀瀀挀攀氀氀猀琀栀爀漀甀最栀挀攀氀氀挀礀挀氀攀愀爀爀攀猀琀愀渀搀愀瀀漀瀀琀漀猀椀猀甀爀倀栀愀爀洀愀挀漀氀伀挀琀嬀崀圀愀椀眀甀琀倀攀琀愀氀甀昀漀琀愀氀椀渀猀攀渀猀椀琀椀稀攀猀搀攀愀琀栀爀攀挀攀瀀琀漀爀椀渀搀甀挀攀搀愀瀀
8、漀瀀琀漀猀椀猀瘀椀愀椀搀愀渀搀匀吀吀搀攀瀀攀渀搀攀渀琀瀀愀琀栀眀愀礀猀渀琀伀渀挀漀氀愀渀嬀崀匀甀攀琀愀氀渀瘀漀氀瘀攀洀攀渀琀漀昀挀愀猀瀀愀猀攀猀愀渀搀愀瀀漀瀀琀漀猀椀猀椀渀搀甀挀椀渀最昀愀挀琀漀爀椀渀戀甀昀漀琀愀氀椀渀椀渀搀甀挀攀搀愀瀀漀瀀琀漀猀椀猀漀昀攀瀀挀攀氀氀猀最爀椀挀漀漀搀栀攀洀愀渀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀
9、挀漀洀攀搀栀攀洀砀瀀爀攀猀猀(币匀需翹襧谀币萂币币讀缁缀止測漁螏頀h堀椀紂愃鄃醃鄃刃倀匀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀刀倀匀匀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀攀昀攀搀挀搀昀挀攀愀搀搀唀砀最渀愀爀昀伀攀伀搀爀稀樀娀漀刀一堀漀堀愀倀礀嘀椀一礀瀀唀氀礀最刀倀匀匀攀搀栀攀洀砀瀀爀攀猀猀愀搀搀攀攀愀攀攀挀搀搀攀栀K攀搀栀攀洀砀瀀爀攀猀猀靓刀言茀渀7币媹:/嘀仃甼胔-輀3棙i缀$Roflumilast-Impurity-E-DataSheet-MedChemExpress.pdfpic1.gifRoflumilastImpurityEDataSheetMedChemExpress.pdf20
10、19-531318b172f-7ad4-4989-9c4f-7f1217e01b6biCTCkxBAeVhlYklk0m/et4+pzpBsBYDe+StVSwUCKhkO6eWUlJvSPA=Roflumilast,Impurity,DataSheet,MedChemExpress9d1b5d452dd695f47e5d64169173c33dRoflumilast Impurity ECat. No.: HY-100640CAS No.: 1391052-76-8Molecular Formula: CHClFNOMolecular Weight: 349.12Target: Phosph
11、odiesterase (PDE)Pathway: Metabolic Enzyme/ProteaseStorage: Please store the product under the recommended conditions in the COA.Solvent & SolubilityIn Vitro 10 mM in DMSOConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 2.8643 mL 14.3217 mL 28.6434 mL5 mM 0.5729 mL 2.8643 mL 5.7287 mLPreparing Stock So
12、lutions10 mM 0.2864 mL 1.4322 mL 2.8643 mLPlease refer to the solubility information to select the appropriate solvent.BIOLOGICAL ACTIVITYDescription Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast(Daliresp) is a drug which acts as a selective and long-acting inhibitor of the enzy
13、me PDE-4 with an IC50 value of 0.8 nM.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAProduct Data Sheet InhibitorsAgonistsScreening
14、 Librarieswww.MedChemE1MedChemExpress0001500006先进医疗20190531140726241887R0谗(币匀欀鐀币币币讀缁缀倀渱漁螏頀h堀椀椂謃謃謃鴃鴉鴉）刉漀昀氀甀洀椀氀愀猀琀一漀砀椀搀攀一刀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀刀漀昀氀甀洀椀氀愀猀琀一漀砀椀搀攀一刀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀挀戀挀愀挀挀搀砀夀唀渀洀戀琀昀昀吀渀堀琀戀最昀最挀瀀戀唀搀栀戀搀礀洀樀礀娀猀一爀甀最刀漀昀氀甀洀椀氀愀猀琀漀砀椀搀攀一刀攀搀栀攀洀砀瀀爀攀猀猀愀搀搀搀挀搀愀搀戀攀昀搀攀戀瀀瀀洀琀愀琀攀攀挀漀挀甀洀攀渀琀猀吀椀琀氀攀愀琀愀氀漀最一漀夀愀琀挀栀匀瀀攀挀琀
15、爀甀洀吀椀琀氀攀夀开娀圀夀儀爀攀焀甀攀渀挀礀稀昀伀爀椀最椀渀愀氀倀漀椀渀琀猀漀甀渀琀昀挀琀甀愀氀倀漀椀渀琀猀漀甀渀琀昀挀焀甀椀猀椀琀椀漀渀吀椀洀攀猀攀挀昀匀瀀攀挀琀爀愀氀圀椀搀琀栀瀀瀀洀昀倀甀氀猀攀倀爀漀最爀愀洀唀渀欀渀漀眀渀匀愀洀瀀氀攀娀圀夀儀愀琀愀氀漀最一漀夀愀琀挀栀匀伀伀一伀一伀氀氀伀栀攀洀椀挀愀氀漀爀洀甀氀愀氀一伀砀愀挀琀愀猀猀攀搀栀攀洀砀瀀爀攀猀猀靓刀茀渀7萀币:枪炌胔-抦k輀棙i缀$莑RIPA-56-SDS-MedChemExpress.pdfpic1.gifRIPA56SDSMedChemExpress.pdf2019-5318de2fedc-3df5-4c26-830e-a68
16、791d7735d8UxgnaK3KB4rIfO3eOdrzj9ZAoRN4XBo6XaPGy+ViN5y8pUB8l7y8g=RIPA,56,SDS,MedChemExpressa53546536dd8e45eae21e3cd4d84e752欀MedChemExpress0001500006先进医疗20190531140726147121R刀(搀币搀椀币蠂币搀币讀缁缀淹漁螏頀h椀鴂儃儃儃鄃挃挋挋缋錋鬋鬋鬋愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀愀搀戀戀挀戀戀搀搀戀戀挀戀一夀儀堀眀圀圀椀眀嘀最搀稀圀猀搀眀甀儀愀愀刀漀猀渀瀀愀栀甀堀
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