1、AGN 194078Cat. No.: HY-100273CAS No.: 321995-62-4Molecular Formula: CHFNOMolecular Weight: 403.42Target: RAR/RXRPathway: Metabolic Enzyme/ProteaseStorage: Please store the product under the recommended conditions in the COA.Solvent RAR, Kd: 3 nMIn Vitro AGN 194078 is a selective RAR agonist and bind
2、s to RAR with very high affinity, having a Kd value of 3 nM, while being unable to bind to RAR and binding only very weakly (Kd=5600 nM) to RAR. Furthermore, AGN 194078 maintains full transcriptional activity through RAR, with an EC50 value of 112 nM, but only activatedRAR and RAR with about 10% eff
3、icacy at the highest dose (1000 nM) tested1.REFERENCES1. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.Product Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2
