1、 Inhibitors, Agonists, Screening Librarieswww.MedChemEData SheetBIOLOGICAL ACTIVITY: Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, includingepatoprotective, nephroprotective, antiinflammatory, antioxidant, anticancer, and antimicrobia
2、l activities.IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogenactivated protein (MAP) kinase activation inhuman colon adenocarcinoma cells (Caco2) but significantly lessened H2O2induced DNA damage and the elevated MDA and ROSlevels induced by H2O
3、2/Fe2+ at the concentrations of 0.110 mg/mL 1.In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated theexpression of SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteralob
4、struction. Rhein also suppressed TGF1 and its type I receptor expression in obstructed kidneys 1. The biochemical parametersresults of IgAN model rats showed that rheinprevented and rheintreated both improved the biochemical parameters and relievedrenal pathological injury. The expressions of renal
5、tissue TLR4, TGF1, but not TLR9 were significantly elevated in IgAN model rats (P 0.05). Rheinprevented and rheintreated both inhibited TLR4 and TGF1 expressions 2.References: 1. Xiaowen Chen, et al. Tolllike receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Ind
6、ian J Pharmacol. 2015 JanFeb;47(1): 2733.2. Hou ML, et al. The DrugDrug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In VivoMicrodialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):12534.3. YanXi Zhou, et al. Rhein: A Review of Pharmacolo
7、gical Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107.Product Name: RheinCat. No.: HY-N0105CAS No.: 478-43-3Molecular Formula:C15H8O6Molecular Weight: 284.22Target: AutophagyPathway: AutophagySolubility: DMSO: 12.17 mg/mL (Need ultrasonic and warming)Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE
