1、BDA-410Cat. No.: HY-111808CAS No.: 147660-55-7Molecular Formula: CHNOSMolecular Weight: 484.61Target: ProteasomePathway: Metabolic Enzyme/ProteaseStorage: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITYDescription BDA-410 is a cysteine protease inhibitor with
2、 ki values of 130 nM and 630 nM for calpain-1 and calpain-2, respevtively. BDA-410 inhibits recombinant falcipain-2B with an IC50 of 628 nM and exhibits anti-malarial effects1.IC i.p. injection for three times per day; 4 days) rapidly clears parasitemia in vivo resulting in 72% inhibition with no ob
3、vious detrimental effects due to inhibitor treatment in infected mice. All BDA-410 treated mice survive for longer1.Animal Model: C57BL/6 mice (4-6 weeks of age, 20-22g of weight)1Dosage: 25 mg/kgAdministration: Given i.p. injection; three times per day for 4 daysResult: Rapidly cleared parasitemia
4、in vivo resulting in 72% inhibition with no obvious detrimental effects due to inhibitor treatment in infected mice.BDA-410 treated mice survived until around day 23 compared with control group; and two of the eight BDA-410 treated mice survived until day 60.REFERENCES1. Xuerong Li, et al. BDA-410:
5、A novel synthetic calpain inhibitor active against blood stage malaria. Mol Biochem Parasitol. 2007 Sep; 155(1): 2632.McePdfHeightProduct Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2
