1、BPN14770Cat. No.: HY-117571CAS No.: 1606974-33-7Molecular Formula: CHClFNOMolecular Weight: 405.8Target: Phosphodiesterase (PDE)Pathway: Metabolic Enzyme/ProteaseStorage: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITYDescription BPN14770 is a selective phosp
2、hodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3 (two different dimeric forms of PDE4D), respectively1.IC p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg2.Animal Model: C57Bl6 mice2Dosag
3、e: 0.1, 0.3, 1, 3, 10, 30 mg/kgAdministration: p.o.; 24 hoursResult: Significantly improved novel object discrimination at doses above 0.3 mg/kg.REFERENCES1. Ricciarelli R, et al. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimers disease. Sci
4、 Rep. 2017 Apr 12;7:46320.2. Gurney ME, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J Med Chem. 2019 May 23;62(10):4884-4901.McePdfHeightProduct Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2
