1、Bragsin1Cat. No.: HY-111549CAS No.: 369631-68-5Molecular Formula: CHFNOMolecular Weight: 273.16Target: OthersPathway: OthersStorage: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITYDescription Bragsin1 is a potent, selective and noncompetitive inhibitor of the
2、 ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 M. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity1.IC & Target IC50: 3 M (BRAG2)1REFERENCES1. Nawrotek A, et al. PH-
3、domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAProduct Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE1
