1、(吀艆爁搀愀秀耀猀艉爁吀艆爁讀缁缀堀躯缀螏頀h椀餂謃弃弎弎笎輎霎霎霎愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀戀攀戀攀挀戀愀攀昀昀昀昀夀戀猀甀匀匀眀渀漀倀愀戀瀀吀洀渀砀刀儀唀搀唀儀圀欀甀渀漀甀儀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀昀戀愀挀愀攀昀愀挀愀戀昀攀搀昀愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀舀舠脀蜠氀一伀萀漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀倀爀漀猀琀愀最氀愀渀搀椀渀刀攀挀攀瀀琀漀爀倀愀琀栀眀愀礀倀刀倀爀漀琀攀椀渀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀爀
2、攀瘀攀爀猀攀猀琀栀攀椀渀栀椀戀椀琀漀爀礀攀昀昀攀挀琀猀漀昀倀漀渀倀匀椀渀搀甀挀攀搀吀一瀀爀漀搀甀挀琀椀漀渀椀渀愀挀漀渀挀攀渀琀爀愀琀椀漀渀搀攀瀀攀渀搀攀渀琀洀愀渀渀攀爀嬀崀椀渀瘀椀瘀漀猀椀最渀椀昀椀挀愀渀琀氀礀搀攀氀愀礀猀琀栀攀甀氀挀攀爀栀攀愀氀椀渀最椀渀爀愀琀猀愀渀搀洀椀挀攀吀栀攀攀砀瀀爀攀猀猀椀漀渀漀昀嘀椀渀瀀爀椀洀愀爀礀爀愀琀最愀猀琀爀椀挀昀椀戀爀漀戀氀愀猀琀猀眀愀猀椀渀挀爀攀愀猀攀搀戀礀倀漀爀倀愀最漀渀椀猀琀愀渀搀琀栀攀猀攀爀攀猀瀀漀渀猀攀猀眀攀爀攀戀漀琀栀愀琀琀攀渀甀愀琀攀搀戀礀挀漀愀搀洀椀渀椀猀琀爀愀琀椀漀渀漀昀嬀崀刀刀一匀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀
3、琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀嬀崀甀爀愀猀攀攀琀愀氀渀瘀椀琀爀漀瀀栀愀爀洀愀挀漀氀漀最椀挀愀氀挀栀愀爀愀挀琀攀爀椀稀愀琀椀漀渀漀昀愀渀漀瘀攀氀瀀漀琀攀渀琀愀渀搀猀攀氀攀挀琀椀瘀攀瀀爀漀猀琀愀最氀愀渀搀椀渀倀爀攀挀攀瀀琀漀爀愀渀琀愀最漀渀椀猀琀椀昀攀匀挀椀愀渀嬀崀愀琀愀稀愀眀愀刀攀琀愀氀礀挀氀漀漀砀礀最攀渀愀猀攀瀀爀漀猀琀愀最氀愀渀搀椀渀愀挀挀攀氀攀爀愀琀攀猀琀栀攀栀攀愀氀椀渀最漀昀最愀猀琀爀椀挀甀氀挀攀爀猀瘀椀愀倀爀攀挀攀瀀琀漀爀猀洀倀栀礀猀椀漀氀愀猀琀爀漀椀渀琀攀猀琀椀瘀攀爀倀栀礀猀椀漀氀伀挀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀
4、瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓Capiravi鎇蘊戀愀氀愀瀀椀爀愀瘀椀爀牁舃蚓脊倀balapiravir-datasheet-medchemexpress.pd戀愀猀攀鎂蘃戀愀猀攀鎇蘃鈞堝鼜猛縙怘鄗戗蠖氖倖愕樔褓欓園笑吐朏谏嬎鄍猍儌鐋砋甊蘎昍礋個踊愊蠉栉頇朆錅丅逄琄礁褀蔀威封嬉嬖鼀言茀渀7艈爁窠:s%胔-輀棙嘘i缀$Cilomilast-Data
5、Sheet-MedChemExpress.pdfpic1.gifCilomilastDataSheetMedChemExpress.pdf2019-620ba76066a-142c-4702-b512-e6e621e11758XBuineWm+HF6ge1T6MgVh/zH9MoYlAyBrgeNHseFvEBm5+N5TaUBgQ=Cilomilast,DataSheet,MedChemExpressd9fce0a51af452c5b83eaf146847cea4CilomilastCat. No.: HY-10790CAS No.: 153259-65-5Molecular Formula
6、: CHNOMolecular Weight: 343.42Target: Phosphodiesterase (PDE)Pathway: Metabolic Enzyme/ProteaseStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system
7、 activity.IC50 value: 110 nMTarget: PDE 4Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki 100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomi
8、last (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.REFERENCES1. MARY S. BARNETTE et al. SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In Vitro Anti-inflammatory Actions JPET 28
9、4:420 -426, 19982. Munisso MC, Kang JH, Tsurufuji M, Yamaoka T.Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2.Biochimie. 2012 Jun 15.Product Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE13. Sadrai Z,
10、Stevenson W, Okanobo A, Chen Y, Do炄(艞爁搀爀搀猀萂艰爁艞爁讀缁缀萀躰缀螏頀h瀀椀鴂儃儃儃鄃：愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀愀愀愀挀昀挀挀攀搀愀椀漀娀猀唀匀唀最渀最一洀攀瘀吀攀圀稀甀戀刀儀椀猀倀洀唀眀嘀一漀伀砀樀稀最最伀最愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀挀昀搀昀攀戀挀昀搀挀愀愀愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀脀蠠脀茠爀一萀传漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀刀倀愀琀栀眀愀礀匀吀吀匀椀最渀愀氀椀渀最倀爀漀琀攀椀渀吀礀爀漀猀椀渀攀椀渀愀猀攀刀吀匀琀漀爀愀最攀倀漀眀搀
11、攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀一攀攀搀甀氀琀爀愀猀漀渀椀挀愀渀搀眀愀爀洀椀渀最漀渀挀攀渀琀爀愀琀椀漀渀匀漀氀瘀攀渀琀愀猀猀洀最洀最洀最洀洀洀洀洀洀洀洀倀爀攀瀀愀爀椀渀最匀琀漀挀欀匀漀氀甀琀椀漀渀猀洀洀洀洀倀氀攀愀猀攀爀攀昀攀爀琀漀琀栀攀猀漀氀甀戀椀氀椀琀礀椀渀昀漀爀洀愀琀椀漀渀琀漀猀攀氀攀挀琀琀栀攀愀瀀瀀爀漀瀀爀椀愀琀攀猀漀氀瘀攀渀琀伀伀吀嘀吀夀攀猀挀爀椀瀀琀椀漀渀圀夀椀猀愀渀椀爀爀攀瘀攀爀猀椀戀氀攀椀渀栀椀戀椀琀漀爀漀昀刀眀椀琀栀漀昀瀀椀猀愀戀氀攀琀漀漀瘀攀爀挀漀洀攀爀攀猀椀猀琀愀渀挀攀挀愀甀猀攀搀戀礀琀栀攀吀洀甀琀愀琀椀漀渀漀渀愀昀甀渀挀琀椀漀
12、渀愀氀氀攀瘀攀氀瘀愀氀甀攀瀀吀愀爀最攀琀刀椀渀瘀椀琀爀漀戀氀漀挀欀攀搀猀琀椀洀甀氀愀琀攀搀愀甀琀漀瀀栀漀猀瀀栀漀爀礀氀愀琀椀漀渀漀昀琀栀攀爀攀挀攀瀀琀漀爀椀渀挀攀氀氀猀椀挀愀瀀瀀爀漀砀椀洀愀琀攀氀礀渀椀渀栀椀戀椀琀攀搀挀攀氀氀瀀爀漀氀椀昀攀爀愀琀椀漀渀渀瀀爀椀洀愀爀椀氀礀椀渀愀挀礀琀漀猀琀愀琀椀挀洀愀渀渀攀爀椀渀挀攀氀氀氀椀渀攀猀琀栀愀琀漀瘀攀爀攀砀瀀爀攀猀猀刀漀爀挀攀爀戀嬀崀圀栀攀爀攀愀猀琀爀愀渀猀昀漀爀洀愀琀椀漀渀戀礀洀漀猀琀刀洀甀琀愀渀琀猀挀漀渀昀攀爀猀漀渀挀攀氀氀猀猀攀渀猀椀琀椀瘀椀琀礀琀漀攀爀氀漀琀椀渀椀戀愀渀搀最攀昀椀琀椀渀椀戀琀爀愀渀猀昀漀爀洀愀琀椀漀渀戀礀愀渀攀砀漀渀椀渀猀攀爀
13、琀椀漀渀洀愀欀攀猀挀攀氀氀猀爀攀猀椀猀琀愀渀琀琀漀琀栀攀猀攀椀渀栀椀戀椀琀漀爀猀戀甀琀洀漀爀攀猀攀渀猀椀琀椀瘀攀琀漀琀栀攀椀爀爀攀瘀攀爀猀椀戀氀攀椀渀栀椀戀椀琀漀爀嬀崀椀猀愀戀氀攀琀漀漀瘀攀爀挀漀洀攀爀攀猀椀猀琀愀渀挀攀挀愀甀猀攀搀戀礀琀栀攀吀洀甀琀愀琀椀漀渀漀渀愀昀甀渀挀琀椀漀渀愀氀氀攀瘀攀氀挀漀爀爀攀氀愀琀椀渀最眀椀琀栀攀昀昀攀挀琀椀瘀攀椀渀栀椀戀椀琀椀漀渀漀昀搀漀眀渀猀琀爀攀愀洀猀椀最渀愀氀椀渀最瀀愀琀栀眀愀礀猀嬀崀椀渀瘀椀瘀漀瀀爀漀昀漀甀渀搀氀礀戀氀漀挀欀攀搀琀栀攀最爀漀眀琀栀漀昀愀琀甀洀漀爀琀栀愀琀漀瘀攀爀攀砀瀀爀攀猀猀攀猀刀椀渀渀甀搀攀洀椀挀攀眀栀攀渀最椀瘀攀渀漀爀愀氀氀礀愀琀洀最
14、欀最搀愀礀昀漀爀搀愀礀猀搀愀椀氀礀嬀崀吀爀攀愀琀洀攀渀琀漀昀倀洀椀挀攀眀椀琀栀爀攀猀甀氀琀攀搀椀渀愀洀愀爀欀攀搀爀攀搀甀挀琀椀漀渀漀昀挀漀氀氀攀挀琀椀渀最琀甀戀甀氀攀吀挀礀猀琀椀挀氀攀猀椀漀渀猀椀洀瀀爀漀瘀攀搀爀攀渀愀氀昀甀渀挀琀椀漀渀搀攀挀爀攀愀猀攀搀戀椀氀椀愀爀礀攀瀀椀琀栀攀氀椀愀氀愀戀渀漀爀洀愀氀椀琀椀攀猀愀渀搀愀渀椀渀挀爀攀愀猀攀搀氀椀昀攀猀瀀愀渀礀猀琀椀挀愀渀椀洀愀氀猀琀爀攀愀琀攀搀眀椀琀栀琀漀瀀漀猀琀渀愀琀愀氀搀愀礀倀眀攀爀攀愀氀椀瘀攀愀渀搀眀攀氀氀眀椀琀栀渀漀爀洀愀氀爀攀渀愀氀昀甀渀挀琀椀漀渀愀爀攀搀甀挀攀搀吀挀礀猀琀椀挀椀渀搀攀砀漀昀倀氀琀愀琀栀爀攀攀昀漀氀搀椀渀挀爀攀愀猀攀搀
15、椀渀洀愀砀椀洀甀洀甀爀椀渀愀爀礀挀漀渀挀攀渀琀爀愀琀椀渀最愀戀椀氀椀琀礀倀氀琀愀渀搀愀猀椀最渀椀昀椀挀愀渀琀搀攀挀爀攀愀猀攀椀渀戀椀氀椀愀爀礀攀瀀椀琀栀攀氀椀愀氀瀀爀漀氀椀昀攀爀愀琀椀漀渀昀椀戀爀漀猀椀猀倀氀琀嬀崀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀蔀耠嬀崀匀眀攀攀渀攀礀圀攀琀愀氀吀爀攀愀琀洀攀渀琀漀昀瀀漀氀礀挀礀猀琀椀挀欀椀搀渀攀礀搀椀猀攀愀猀攀眀椀琀栀愀渀漀瘀攀氀琀礀爀漀猀椀渀攀欀椀渀愀猀攀椀渀栀椀戀椀琀漀爀椀搀渀攀礀渀琀愀渀嬀崀爀攀甀氀椀挀栀攀琀愀氀伀渀挀漀最攀渀椀挀琀爀愀渀猀昀漀爀洀愀琀椀漀渀
16、戀礀椀渀栀椀戀椀琀漀爀猀攀渀猀椀琀椀瘀攀愀渀搀爀攀猀椀猀琀愀渀琀刀洀甀琀愀渀琀猀倀漀匀攀搀一漀瘀攀嬀崀漀戀愀礀愀猀栀椀匀攀琀愀氀渀愀氀琀攀爀渀愀琀椀瘀攀椀渀栀椀戀椀琀漀爀漀瘀攀爀挀漀洀攀猀爀攀猀椀猀琀愀渀挀攀挀愀甀猀攀搀戀礀愀洀甀琀愀琀椀漀渀漀昀琀栀攀攀瀀椀搀攀爀洀愀氀最爀漀眀琀栀昀愀挀琀漀爀爀攀挀攀瀀琀漀爀愀渀挀攀爀刀攀猀甀最愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀
17、漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓阄(艴爁搀爀猀芖爁艴爁讀缁缀躲缀螏頀h椀鬂謃一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀挀戀攀愀昀愀愀愀搀挀搀搀挀戀堀甀栀攀最倀愀栀一刀夀唀焀瀀甀挀搀椀礀焀伀猀欀爀椀眀欀戀嘀娀愀猀眀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀攀愀愀昀攀昀戀戀搀挀一愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀舀萠脀蘠一蔀传漀氀攀挀甀氀愀爀圀攀椀最栀琀吀愀爀最攀琀倀愀琀栀眀愀礀攀氀氀礀挀氀攀一愀洀愀最攀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀
18、匀漀氀瘀攀渀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓言茀渀7芗爁虀:軼r筐%霰軼胔-輀棙塰i缀$Cobicistat-DataSheet-MedChemExpress.pdfpic1.gifCobicistatDataSheetMedChemExpress.pdf2019-6207d84761a-7
19、979-4a03-ae43-32e8ec4ae0f1x3BsFBE1l0QrkDhqFtrd9tcyLEb1EhZOuGr1Vw3RBk+2gtEzDYHsJw=Cobicistat,DataSheet,MedChemExpressbe27bcbce2141495f8b6fd78a8a234f6CobicistatCat. No.: HY-10493CAS No.: 1004316-88-4Molecular Formula: CHNOSMolecular Weight: 776.02Target: Cytochrome P450Pathway: Metabolic Enzyme/Protea
20、seStorage: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 monthSolvent 49(4):233-7.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, N
21、J 08852, USA Drug Metab Lett. 2016;10(2):111-23.www.MedChemE2MedChemExpress0001500006先进医疗20190620091942906999C阄(艴爁搀爀猀芖爁艴爁讀缁缀躲缀螏頀h椀鬂謃一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀挀戀攀愀昀愀愀愀搀挀搀搀挀戀堀甀栀攀最倀愀栀一刀夀唀焀瀀甀挀搀椀礀焀伀猀欀爀椀眀欀戀嘀娀愀猀眀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀攀愀愀昀攀昀戀戀搀挀一愀琀一漀夀匀一漀漀氀攀挀甀氀愀爀漀爀洀甀氀愀舀萠脀蘠一蔀传漀氀攀挀甀氀
22、愀爀圀攀椀最栀琀吀愀爀最攀琀倀愀琀栀眀愀礀攀氀氀礀挀氀攀一愀洀愀最攀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓鎂蛬椀渀栀椀戀椀琀漀爀牁蜃蚓臬inhibitor鎂蚲椀
23、猀漀瀀攀瀀琀椀搀愀猀攀牁蜃蚓膲isopeptidas鎂蘋洀攀搀挀栀攀洀攀砀瀀爀攀猀猀贐鸐鼐!預!騐!鬐!谐!贐!鸀!輐!蠐褐!倰瀰偀偀倰偐灐倰怰偀吀耀(頀芧爁搀尀猀芽爁頀芧爁讀缁缀谀躷缀螏頀h椀匂欃欃欃漀氀攀猀琀礀爀愀洀椀渀攀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀漀氀攀猀琀礀爀愀洀椀渀攀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀戀挀昀挀搀昀戀挀昀攀挀搀昀最攀圀瀀攀礀琀洀挀匀攀眀氀嘀一椀栀挀琀倀稀最礀漀吀刀猀漀椀搀瘀洀甀礀最漀氀攀猀琀礀爀愀洀椀渀攀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀昀戀昀愀搀愀挀搀戀挀愀戀漀氀攀猀琀礀爀愀洀椀渀攀愀琀一漀夀匀一漀吀愀爀最攀琀伀琀栀攀爀
24、猀倀愀琀栀眀愀礀伀琀栀攀爀猀匀琀漀爀愀最攀倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀匀漀氀瘀攀渀琀匀倀漀渀琀爀漀氀搀椀攀琀昀漀爀眀攀攀欀猀昀漀氀氀漀眀椀渀最戀礀漀爀愀氀最愀瘀愀最攀眀椀琀栀洀最欀最匀倀昀漀爀栀爀猀夀漀氀攀猀琀礀爀愀洀椀渀攀挀栀漀氀攀猀琀礀爀愀洀椀渀攀漀氀攀猀琀礀爀愀洀椀渀攀挀栀漀氀攀猀琀礀爀愀洀椀渀攀猀甀瀀瀀氀攀洀攀渀琀椀渀最搀椀攀琀昀漀爀眀攀攀欀猀昀漀氀氀漀眀椀渀最戀礀漀爀愀氀最愀瘀愀最攀眀椀琀栀瘀攀栀椀挀氀攀昀漀爀栀爀猀愀渀搀夀漀氀攀猀琀礀爀愀洀椀渀攀渀椀洀愀氀搀洀椀渀椀猀琀爀愀琀椀漀渀嬀崀倀爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀
25、猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀挀栀漀氀攀猀琀礀爀愀洀椀渀攀匀倀挀栀漀氀攀猀琀礀爀愀洀椀渀攀猀甀瀀瀀氀攀洀攀渀琀椀渀最搀椀攀琀昀漀爀眀攀攀欀猀昀漀氀氀漀眀椀渀最戀礀漀爀愀氀最愀瘀愀最攀眀椀琀栀洀最欀最匀倀昀漀爀栀爀猀氀漀漀搀椀猀挀漀氀氀攀挀琀攀搀昀爀漀洀琀栀攀漀爀戀椀琀愀氀瀀氀攀砀甀猀甀渀搀攀爀椀猀漀昀氀甀爀愀渀攀愀渀攀猀琀栀攀猀椀愀愀渀搀椀渀琀攀猀琀椀渀攀猀愀渀搀氀椀瘀攀爀猀愀爀攀猀渀愀瀀昀爀漀稀攀渀椀渀氀椀焀甀椀搀渀椀琀爀漀最攀渀愀渀搀猀琀漀爀攀搀愀琀甀渀琀椀氀甀猀攀琀琀栀攀猀琀愀爀琀漀昀琀栀攀栀爀攀砀瀀攀爀椀洀攀渀琀洀椀挀攀愀爀攀瀀氀愀挀攀搀椀渀
26、琀漀挀氀攀愀渀挀愀最攀猀愀渀搀昀攀挀攀猀愀爀攀洀愀渀甀愀氀氀礀挀漀氀氀攀挀琀攀搀愀琀琀栀攀攀渀搀漀昀琀栀攀猀琀甀搀礀嬀崀栀愀猀渀漀琀椀渀搀攀瀀攀渀搀攀渀琀氀礀挀漀渀昀椀爀洀攀搀琀栀攀愀挀挀甀爀愀挀礀漀昀琀栀攀猀攀洀攀琀栀漀搀猀吀栀攀礀愀爀攀昀漀爀爀攀昀攀爀攀渀挀攀漀渀氀礀刀刀一匀嬀崀愀甀最攀愀椀猀攀琀愀氀爀愀搀洀椀渀椀猀琀爀愀琀椀漀渀椀渀挀爀攀愀猀攀猀爀攀瘀攀爀猀攀挀栀漀氀攀猀琀攀爀漀氀琀爀愀渀猀瀀漀爀琀椀渀洀椀挀攀戀甀琀椀猀渀漀琀愀搀搀椀琀椀瘀攀漀渀琀漀瀀漀昀攀稀攀琀椀洀椀戀攀漀爀挀栀漀氀攀猀琀礀爀愀洀椀渀攀琀爀攀愀琀洀攀渀琀琀栀攀爀漀猀挀氀攀爀漀猀椀猀甀氀嬀崀刀攀戀攀挀挀愀攀椀搀欀攀爀攀琀愀氀爀愀瀀攀匀攀攀搀倀爀漀挀礀愀渀椀搀椀渀猀愀渀搀栀漀氀攀猀琀礀爀愀洀椀渀攀椀昀昀攀爀攀渀琀椀愀氀氀礀氀琀攀爀椀氀攀挀椀搀愀渀搀栀漀氀攀猀琀攀爀漀氀漀洀攀漀猀琀愀琀椀挀攀渀攀砀瀀爀攀猀猀椀漀渀椀渀漀甀猀攀渀琀攀猀琀椀渀攀愀渀搀椀瘀攀爀倀漀匀伀渀攀攀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀搀搀爀攀猀猀攀攀爀倀愀爀欀爀匀甀椀琀攀儀漀渀洀漀甀琀栀甀渀挀琀椀漀渀一唀匀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀漀洀攀搀栀攀洀砀瀀爀攀猀猀靓
