1、(砀搀最砀萂砀砀讀缁缀鄼缀螏頀h椀焃朋笋茋茋茋刀椀氀愀渀攀猀椀戀刀刀刀夀椀渀攀猀椀渀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀刀椀氀愀渀攀猀椀戀刀刀刀夀椀渀攀猀椀渀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀昀挀戀攀戀昀唀刀漀欀稀眀渀堀椀嘀氀圀椀欀砀焀搀匀栀伀圀猀伀娀砀夀夀猀伀唀愀樀娀稀漀娀儀椀氀愀渀攀猀椀戀刀刀夀椀渀攀猀椀渀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀愀愀愀搀挀戀挀愀愀挀戀刀椀氀愀渀攀猀椀戀愀琀一漀夀匀一漀舀耠舀舠舀丠萀传舀匠尀摏瘯椀渀攀猀椀渀尀摏攀氀氀礀挀氀攀一愀洀愀最攀礀琀漀猀欀攀氀攀琀漀渀塐倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀
2、琀栀灠湥卣鹙豛匀伀攀洀最洀洀伀最琀挀漀爀渀漀椀氀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀倀最琀最琀吀眀攀攀渀最琀最琀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀伀伀吀嘀吀夀挀椯刀椀氀愀渀攀猀椀戀刀刀刀夀刀刀夀萀刀謀厕煏榆匀倀鄀渀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶偞爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最
3、漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓言茀渀7萀砀樼:gM胔-輀a棙i缀$(S)-Gossypol-acetic-acid-(S)-(+)-Gossypol-acetic-acid)-Bcl-2-Family-Inhibitor-MedChemExpress.pdfpic1.gif(S)Gossypolaceticacid(S)()Gossypolaceticacid)Bcl2FamilyInhibitorMedChemExpress.pdf2019-625a9b6257b-d7a9-426c-80ec-a72d94f43a13T
4、qD96ei7bBDE5zHxQ1AFlONWCTjpZfsowiLGxvirUrQcTekt43Xicw=Gossypol,acetic,acid,Bcl,Family,Inhibitor,MedChemExpressf45032b8fb9589001f63d232f6a618c2(S)-Gossypol acetic acidCat. No.: HY-15464DCAS No.: 1189561-66-7分式: CHO分量: 578.61作靶点: Bcl-2 Family作通路: Apoptosis储存式: -20C, protect from light, stored under ar
5、gon溶解性数据体外实验 DMSO : 50 mg/mL (86.41 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.32 mM); Clear solution1. BIOLOGICAL ACTIVITY物活性 (S)-Gossypol acetic acid 是天然产物 Gossypol 的异构体 。 (S)-Gossypol 以亲和结合到 Bcl-xL 和 Bcl-2 蛋的 BH3 结合沟 。IC 10(22):7757-63.McePdfHeightCaution:
6、 Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE2MedChemExpress0001500006先进医疗20190625154443332354?0(砀搀最砀萂砀砀讀缁缀頀鄿缀螏頀h椀褂欃匈匈匈匈匈匈匈匈匈匈匈匈匈匈匈匈匈匈唈娀攀搀栀攀洀砀瀀爀
7、攀猀猀瀀搀昀瀀椀挀最椀昀娀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀挀挀戀愀戀戀愀戀昀戀挀挀攀挀洀刀椀昀最漀嘀瘀洀焀昀稀最椀圀圀樀儀倀倀唀樀眀刀圀娀渀娀眀昀椀吀夀唀攀礀儀攀搀栀攀洀砀瀀爀攀猀猀戀戀愀愀愀愀戀戀搀戀戀攀搀娀愀琀一漀夀匀一漀脀蠠脀脠氀舀丠伀萀尀摏瘯伀琀栀攀爀猀尀摏伀琀栀攀爀猀塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯娀萀窕葟挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀
8、洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶偞爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓(尀砀搀最退砀萂砀尀砀讀缁缀酁缀螏頀h椀愃愃愃攊攊攊攊攊攊攊攊攊攊攊攊攊攊攊攊攊攊朊圊夀洀吀伀刀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀圀夀洀吀伀刀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀愀戀愀愀攀戀挀攀搀戀昀爀洀琀洀甀渀搀焀椀攀漀愀稀渀栀椀氀猀眀唀猀椀洀昀瀀甀琀最圀夀洀吀伀刀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀挀攀昀攀戀愀愀攀昀戀
9、愀昀搀圀夀愀琀一漀夀匀一漀舀蠠茀舠丠蠀传茀尀摏瘯洀吀伀刀倀尀摏倀欀琀洀吀伀刀塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯圀夀f吀倀襺葠洀吀伀刀鄀渀圀夀鄀洀吀伀刀谀洀吀伀刀圀夀开酎倀谀倀渀谀蔀耠嬀崀栀攀渀最攀琀愀氀倀爀攀挀氀椀渀椀挀愀氀攀瘀愀氀甀愀琀椀漀渀漀昀圀夀愀洀吀伀刀欀椀渀愀猀攀椀渀栀椀戀椀琀漀爀愀猀愀瀀漀琀攀渀琀椀愀氀愀渀琀椀愀挀甀琀攀洀礀攀氀漀椀搀氀攀甀欀攀洀椀愀愀最攀渀琀椀漀挀栀攀洀椀漀瀀栀礀猀刀攀猀漀洀洀甀渀攀戀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀
10、愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓圀言茀渀7萀砀揧:gM胔-輀(棙i缀$WZ811-CXCR-Antagonist-MedChemExpress.pdfpic1.gifWZ811CXCRAntagonistMedChemExpress.pdf2019-6254828743b-a018-4854-9798-0f730bad8666Wtb6SBS9jtMczybCr+nuBSnJnmsbolgO
11、nzvA5sSEuzeS1bWwAoVu5Q=WZ811,CXCR,Antagonist,MedChemExpress44751a8214923cc08b4caa7cba583dafWZ811Cat. No.: HY-15478CAS No.: 55778-02-4分式: CHN分量: 290.36作靶点: CXCR作通路: GPCR/G Protein; Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 10 mg/mL (
12、34.44 mM; Need ultrasonic)ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 3.4440 mL 17.2200 mL 34.4400 mL5 mM 0.6888 mL 3.4440 mL 6.8880 mL制备储备液10 mM 0.3444 mL 1.7220 mL 3.4440 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液体内实验 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 1 mg/mL (3.44 mM); Clear solution1. 请依序添加每种溶剂：
13、 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1 mg/mL (3.44 mM); Clear solution2. BIOLOGICAL ACTIVITY物活性 WZ811 是种有效的 CXCR4 拮抗剂，能够抑制 TN14003 与 CXCR4 结合， EC50 值为 0.3 nM。IC 50(23):5655-64.2. Li SH, et al. Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811. Am J Transl Re
14、s. 2016 Sep 15;8(9):3812-3821.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE2MedChemExpress0001500006先进医疗20190625154553037353
15、W裻!觋偀怰倰倰灐鄰怰恠倰瘀猀愀氀琀鎇蚭踂騐骙脘!让躎麌裻!觋言恀倰怰偀偀倰偐娀鎂蘥!猀愀渀最甀椀渀愀爀椀渀攀鎇蘥!猀愀渀最甀椀渀愀爀椀渀攀猀愀渀琀鎂蛴san蝴蚓菔鎂蛔F猀愀渀琀挀漀愀洀攀搀挀栀攀洀攀砀瀀爀攀猀猀瀀搀昀牁舃蚓致sant-1-datasheet-medchemexpress.pd鎂蛕:猀愀渀琀猀搀猀洀攀搀挀栀攀洀攀砀瀀爀攀猀猀瀀搀昀舅蚓誧莈santacruzamate蜅蚓誧莈santacruzamatea牁sa色蚓膠谀牁sa蝲蚓膠谀牁舃蚓膠谀sar-20347-datasheet-medchemexpress.pd鎂蘵沴sar125844髍蜆蚓葬!猀愀爀鎂蛖L猀愀爀挀漀愀洀攀搀挀
16、栀攀洀攀砀瀀爀攀猀猀瀀搀昀牁舃蚓沴腬sar125844-datasheet-medchemexpress.pd鎂蛗T猀愀爀爀瀀栀瀀氀挀洀攀搀挀栀攀洀攀砀瀀爀攀猀猀瀀搀昀牁舃蚓脵sar125844-sds-medchemexpress.pdf(砀搀最砀萂砀砀讀缁缀琀酅缀螏頀h椀异缃缃缃會朖朖茖霖鼖鼖鼖堖嘀吀愀渀欀礀爀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀堀嘀吀愀渀欀礀爀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀搀攀昀戀昀攀昀愀戀挀昀焀夀稀昀最洀儀琀愀琀昀甀吀倀眀吀欀娀礀甀渀嘀稀砀爀唀儀儀刀夀娀挀椀伀甀昀圀眀堀嘀吀愀渀欀礀爀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀
17、爀攀猀猀攀愀昀挀戀挀攀愀攀堀嘀愀琀一漀夀匀一漀脀萠脀脠茀丠舀传匀尀摏瘯倀刀倀挀愀琀攀渀椀渀尀摏攀氀氀礀挀氀攀一愀洀愀最攀瀀椀最攀渀攀琀椀挀猀匀琀攀洀攀氀氀圀渀琀塐倀漀眀搀攀爀礀攀愀爀猀礀攀愀爀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀猀洀漀渀琀栀灠湥卣鹙豛匀伀洀最洀洀一攀攀搀甀氀琀爀愀猀漀渀椀挀愀渀搀眀愀爀洀椀渀最漀渀挀攀渀琀爀愀琀椀漀渀匀漀氀瘀攀渀琀愀猀猀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐卭蕏鹑豛堀嘀椀猀搀椀猀猀漀氀瘀攀搀椀渀猀漀搀椀甀洀挀栀氀漀爀椀搀攀嬀崀伀伀吀嘀吀夀挀椯堀嘀媕癔琀愀渀欀礀爀愀猀攀吀一匀鄀忿董圀渀琀挀愀琀攀渀椀渀猀椀最渀愀氀椀渀最鄀鄀吀一匀谀吀一匀萀谀渀蔀耠倀爀漀挀一愀琀氀挀愀搀
18、匀挀椀唀匀愀爀渀瘀攀猀琀攀爀洀愀琀漀氀愀渀攀氀氀攀愀琀栀椀猀愀渀攀氀氀倀栀礀猀椀漀氀椀漀挀栀攀洀攀瘀攀氀漀瀀洀攀渀琀一漀瘀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀嬀崀爀攀最愀氀氀愀刀攀琀愀氀刀攀最甀氀愀琀漀爀礀爀漀氀攀猀漀昀琀愀渀欀礀爀愀猀攀愀琀琀攀氀漀洀攀爀攀猀愀渀搀椀渀一爀攀瀀愀椀爀猀甀瀀瀀爀攀猀猀椀漀渀漀昀吀匀愀渀搀猀琀愀戀椀氀椀稀愀琀椀漀渀漀昀一倀挀猀最椀渀最氀戀愀渀礀一夀伀挀琀嬀崀漀攀琀愀氀愀一漀瘀攀氀倀匀洀愀氀氀漀氀攀挀甀氀攀渀栀椀戀椀琀漀爀渀挀爀攀愀猀攀猀愀爀搀椀漀洀礀漀挀礀琀攀倀爀漀最攀渀椀琀漀爀猀愀渀搀倀爀漀洀漀琀攀猀愀爀搀椀愀挀椀昀昀攀爀攀渀琀椀愀琀椀漀渀椀渀漀甀猀攀洀戀爀礀漀渀椀
19、挀匀琀攀洀攀氀氀猀倀漀匀伀渀攀攀嬀崀娀攀渀最攀琀愀氀栀漀渀搀爀漀瀀爀漀琀攀挀琀椀瘀攀攀昀昀攀挀琀猀愀渀搀洀甀氀琀椀琀愀爀最攀琀洀攀挀栀愀渀椀猀洀猀漀昀挀愀爀椀椀渀椀渀戀攀琀愀椀渀搀甀挀攀搀栀甀洀愀渀匀圀挀栀漀渀搀爀漀猀愀爀挀漀洀愀挀攀氀氀猀愀渀搀愀爀愀琀漀猀琀攀漀愀爀琀栀爀椀琀椀猀洀漀搀攀氀渀琀洀洀甀渀漀瀀栀愀爀洀愀挀漀氀愀渀嬀崀愀椀攀琀愀氀瀀椀最攀渀攀琀椀挀搀漀眀渀爀攀最甀氀愀琀椀漀渀漀昀匀刀倀挀漀渀琀爀椀戀甀琀攀猀琀漀攀瀀椀搀攀爀洀愀氀栀礀瀀攀爀瀀氀愀猀椀愀椀渀瀀猀漀爀椀愀猀椀猀洀洀甀渀漀氀愀礀搀漀椀樀椀洀洀甀渀漀氀瀀甀戀愀爀嬀崀一愀爀眀愀氀攀琀愀氀椀猀挀漀瘀攀爀礀漀昀琀愀渀欀礀爀愀猀攀椀
20、渀栀椀戀椀琀椀渀最昀氀愀瘀漀渀攀猀眀椀琀栀椀渀挀爀攀愀猀攀搀瀀漀琀攀渀挀礀愀渀搀椀猀漀攀渀稀礀洀攀猀攀氀攀挀琀椀瘀椀琀礀攀搀栀攀洀伀挀琀嬀崀椀甀攀琀愀氀圀渀琀挀愀琀攀渀椀渀猀椀最渀愀氀椀渀最瀀愀爀琀椀挀椀瀀愀琀攀猀椀渀琀栀攀爀攀最甀氀愀琀椀漀渀漀昀氀椀瀀漀最攀渀攀猀椀猀椀渀琀栀攀氀椀瘀攀爀漀昀樀甀瘀攀渀椀氀攀琀甀爀戀漀琀匀挀漀瀀栀琀栀愀氀洀甀猀洀愀砀椀洀甀猀漀洀瀀椀漀挀栀攀洀倀栀礀猀椀漀氀椀漀挀栀攀洀漀氀椀漀氀愀渀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀
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