1、Bafilomycin A1Cat. No.: HY-100558CAS No.: 88899-55-2分式: CHO分量: 622.83作靶点: Proton Pump; Autophagy作通路: Membrane Transporter/Ion Channel; Autophagy储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (160.56 mM; Need ultrasonic)H2O : 90% corn oilSolubility: 2.5 mg/mL (
2、4.01 mM); Clear solution1. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.01 mM); Suspended solution; Need ultrasonic2. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.01 mM); Clear solution3. BIOLOGICAL ACTIVITY物活性 Bafilomycin A1，种从链霉菌属物种中分离的环内酯
3、类抗素，是特异的 vacuolar-type H+ ATPase (V-ATPase) 抑制剂 。 Bafilomycin A1 抑制噬 1。IC 100(3):345-56.2. Lu X, et al. Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression. Exp Ther Med. 2
4、015 Nov;10(5):1829-1834.3. Ohkuma S, et al. Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase. In Vitro Cell Dev Biol Anim. 1993 Nov;29A(11):862-6. Adv Funct Mater. 2019 Mar. Autophagy. 2019 Mar 25:1-17. Autophagy. 2019 Jan 17:1-14. Theranostics 2018; 8(19):5
5、434-5451. Cancer Lett. 2019 Jun 6. pii: S0304-3835(19)30344-1. www.MedChemE24. Ohta T, et al. Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1. J Pathol. 1998 Jul;185(3):324-30.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE3
