1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE-Amyloid (10-35), amideCat. No.: HY-P1567CAS No.: 181427-66-7分式: CHNOS分量: 2902.33Sequence: Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2Sequence Shortening: YEVHHQKLV
2、FFAEDVGSNKGAIIGLM-NH2作靶点: Amyloid-作通路: Neuronal Signaling储存式: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITY物活性 - Amyloid (10-35), amide 是种含有 26 个氨基酸的多肽，由 - Amyloid 肽的 10-35 残基组成。 -Amyloid (10-35) 是阿尔兹海默症淀粉样斑块 ( Alzheimers disease) 的主要组成成分。体外研究 -Amyloid (10-
3、35) is selected based on the following considerations: (1) -Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) -Amyloid (10-35) retains the ability to add to bona fide Alzhei
4、mers plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, A(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time point
5、s, some of the peptide exists as an amorphous precipitate. In contrast, the use of -Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous f
6、ibrils 1.REFERENCES1. Benzinger TL, et al. Propagating structure of Alzheimers beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12.McePdfHeight1/1 Master of Small Molecules 您边的抑制剂师www.MedChemECaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE2/1 Master of Small Molecules 您边的抑制剂师
