1、諯(凱谀搀鼀%鐂谀讀缁缀孬節貔%頀h鰀椀夁捎x禖啶搀漀挀砀瀀椀挀最椀昀捎x禖啶搀漀挀砀尀尀攀昀攀昀昀搀攀攀昀戀匀搀氀刀伀倀爀最攀唀瀀匀最吀稀戀昀焀礀漀倀椀倀氀圀愀礀倀砀椀栀爀倀樀眀眀x礀啶愀昀搀戀攀愀搀愀挀昀挀搀挀搀昀刀伀捎x禖捎x禖蝧捥罪蟿灎湥魎蕒敷湨c璌獶蕑堰腤捎x禖镠盿驖镎惿祓镠蒍惿祓镠蒍瑎敥鵠鵠瑎鵠瑎镞蝭闿蝺闿蝢棿閐琀魣荳葢齶缰镏禍荳葢腶杨獧襎桛歑葵祔譬盿婞荳齎萠腶翿襒桛琰蜰葎葶刀伀捎x禖捎x禖蒏镶蒍鞘葶捎x禖乾灓靭扻蹗N葠荳豘敧葧葭湎驸摖癢葽敧葵譶鹎豎桛Q眀卑協艳扥蹵祺蹵蹵祎蹵鱥敞蹵赎蹵屔蹵镒蹵驎蹵蹵艎蹵捎x禖荳蹵襎捎x禖覈桛刀伀捎x禖蝧捥罪埿漀爀搀罪湨c璌獶蕑刀伀捎x禖捎x禖啶捎x
2、禖豻捎x禖澀腟W葬遒豪遒鑻捎x禖晹遒浻湞占死氀蕵嵻鼀蕓傏饧魥鑏穝肂讐S荳豓襎桛歒舀遒葧魎邍溑鑓捎x禖鹶浓销靏禑刀伀捎x禖乾歓镓刀伀捎x禖捎x禖礰罓鹢秿捎x禖賿秿罶鹢啒硏砀砀偧沖豓捎x禖捎x禖祗蹏乾湏詏魵鉾汻慥豎憋潎綂賿捎x禖祪扗猀獥飿蝵秿疋豴萠齶杣捎x貃腔晹膋刀伀捎x禖祔扗猀獥兞楻镗恞扗猀獥兞扻猀獥盿华猀獥秿打猀獥讐联讐旿賿穝肂旿邀魮鑏礰瑶飿摑捎x禖祶鸰汒豑汔u膗礰瑶獥飿摑腎敎豬鹔汒礰乾养魿捎x禖祶瑶瓿獥秿瑶叿摑琀瑎艔摑琀秿艠螀邀鱥潧綂鐰荳襓桛荳刀伀捎x禖祔乾啓乾葾璌豒葛啓噥葵答慼楧虓鹒蒈骉葛鉶蕑秿荳葦煶礰虵穝铿齭偓饧豓葛豕葥鹒睛衒摭貖慜葧屶礰镢祔荳豛葎腑賿觿桛捎x禖虵齢恓蒗聎杨獧襒桛歑噥盿湨
3、鹣豓葛葕襶桛歑蓿捎x禖抖歫繰夰樰煘譻葥捎x禖华歺繰煰楓箖筎兞殀豎捎x禖摎蚖杣獧袈膃溋虿答衼腎刀伀捎x禖衢养蠰歭爰襞浼歰桰摖捎x禖衶睾荧蒚襶桛恓洰捎x禖镶葓乾秿镠蒑祢葶镠盿驖镎惿祓镠蒍惿祓镠蒍賿禑禋镫禁秿葶乾票葶瑎敥鵠鵠瑎鵠瑎镞蝭闿蝺闿蝢棿閐琀魣捎x禖捎x禖杣轺葞獧貉鹔坣腓捎x禖偧刀伀捎x禖捎x禖屝覍貈塎豝屝捎x禖喋豾葧祔屝湪驸捎x禖著禑祻讘鱎捗鹗捎x禖屝欰礰祺啓噥豻腒乾乾捎x豜葾璌噥秿葶乾捎x葾耰葾葾葾葧璌腹葧砰砀砀销沍钐蕖W捎x禖祺葶魧乾乾啓魣瑎鵠乾乾葭捾啓豜驺敥婑腹葧礰瑎镞蝭闿蝺棿閐蝢棿閐琀驖镎琀秿睶荧葟鮀豒靔榘鮀匰洀愀氀氀椀爀搀匀(栀搀鼀%栀讀缁缀孬節貔%頀h椀紂鄃鄍鄍匍挀栀椀猀愀渀琀栀
4、攀爀椀渀漀洀椀猀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀匀挀栀椀猀愀渀琀栀攀爀椀渀漀洀椀猀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀搀搀戀昀昀愀昀攀愀愀昀搀戀攀堀琀儀攀洀唀攀戀搀焀夀栀昀刀漀圀栀眀瘀攀攀倀爀洀礀最儀漀唀挀嘀儀氀倀眀匀挀栀椀猀愀渀琀栀攀爀椀渀漀洀椀猀椀渀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀愀搀挀搀愀愀昀昀愀攀愀搀攀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匀挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀匀挀栀椀猀愀渀琀栀攀爀椀渀愀琀一漀夀一匀一漀匀礀渀漀渀礀洀猀漀洀椀猀椀渀匀挀栀椀稀愀渀琀栀攀爀椀渀圀甀眀攀椀稀椀攀猀琀攀爀茀耠茀
5、舠传褀尀摏瘯一尀摏一塐礀攀愀爀猀倀漀眀搀攀爀礀攀愀爀猀洀漀渀琀栀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀灠湥卣鹙豛匀伀攀洀最洀洀伀最琀倀最琀最琀吀眀攀攀渀最琀最琀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀挀漀爀渀漀椀氀匀蕏鹑豛愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀伀伀吀嘀吀夀挀椯匀挀栀椀猀愀渀琀栀攀爀椀渀匀挀栀椀猀愀渀搀爀愀猀瀀栀攀渀愀渀琀栀攀爀愀鰀鹧救葧v匀挀栀椀猀愀渀琀栀攀爀椀渀斉酧瀀一嬀崀娀栀漀甀攀琀愀氀匀挀栀椀猀愀渀琀栀攀爀椀渀瀀爀漀琀攀挀琀猀氀椀瀀漀瀀漀氀礀猀愀挀
6、挀栀愀爀椀搀攀椀渀搀甀挀攀搀愀挀甀琀攀爀攀猀瀀椀爀愀琀漀爀礀搀椀猀琀爀攀猀猀猀礀渀搀爀漀洀攀椀渀洀椀挀攀琀栀爀漀甀最栀椀渀栀椀戀椀琀椀渀最一愀渀搀倀猀猀椀最渀愀氀椀渀最瀀愀琀栀眀愀礀猀渀琀洀洀甀渀漀瀀栀愀爀洀愀挀漀氀匀攀瀀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶攀搀栀攀洀砀瀀爀攀猀猀匀讇耀畭唥0悯(栀搀鼀%栀讀缁缀孬節貔%頀h栀$Schisantherin-A-Gom
7、isin-C-DataSheet-MedChemExpress.pdfpic1.gifSchisantherinAGomisinCDataSheetMedChemExpress.pdf2019-10241d0120d0-1b3f-43f5-a4fe-6a6a7fd014be1XLtQeAm7U+e1bdqJYhfRB0oCWC66hwveePrmLygBQo/UcI4V2QlPw=Schisantherin,Gomisin,DataSheet,MedChemExpress5adcd2aaf539845563516f3ae8ad56e2Hotline: 400-820-3792Inhibitor
8、s Agonists Screening Librarieswww.MedChemESchisantherin ACat. No.: HY-N0694CAS No.: 58546-56-8Synonyms: Gomisin-C; Schizantherin-A; Wuweizi ester-A分式: CHO分量: 536.57作靶点: NF-B作通路: NF-B储存式: -20C 3 yearsPowder4C 2 years-80C 6 monthsIn solvent-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (186.37 mM)H2O : 40% PE
9、G300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.66 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oil体内实验1/3 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (4.66 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Schisantherin A 是从 Schisandra sphenanthera 果实中分离出来的种脂素。 Schisantheri
10、n A 通过 I B 降解来抑制 p65-NF- B 易位进细胞核。IC50 33(2):126-36.2. Zhou E, et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-B and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep;22(1):133-40.McePdfHeightCaution: Product has not
11、been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE3/3 Master of倀(搀%讀缁缀孬節貔%頀h鰀椀茂儂匓挀漀瀀漀氀攀琀椀渀攀氀猀攀洀椀渀椀挀愀挀椀搀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀匀挀漀瀀漀氀攀琀椀渀攀氀猀攀洀椀渀椀挀愀挀椀搀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀昀攀昀挀戀昀戀戀昀愀戀挀瘀戀吀挀刀眀搀娀最儀攀圀樀瘀唀唀栀栀稀倀
12、倀嘀猀砀刀嘀吀猀圀戀倀樀最氀瘀匀挀漀瀀漀氀攀琀椀渀攀氀猀攀洀椀渀椀挀愀挀椀搀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀昀搀挀戀愀戀昀戀攀攀昀戀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匀挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀匀挀漀瀀漀氀攀琀椀渀愀琀一漀夀一匀一漀匀礀渀漀渀礀洀猀攀氀猀攀洀椀渀椀挀愀挀椀搀栀爀礀猀愀琀爀漀瀀椀挀愀挀椀搀脀耠蠀传萀尀摏瘯栀尀摏一攀甀爀漀渀愀氀匀椀最渀愀氀椀渀最塐礀攀愀爀猀倀漀眀搀攀爀礀攀愀爀猀洀漀渀琀栀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀灠湥卣鹙豛匀伀攀洀最洀洀攠洀攀愀渀猀猀漀氀甀戀氀攀戀甀琀猀愀琀甀爀愀琀椀漀渀甀渀欀渀漀眀渀愀猀猀匀漀氀瘀攀渀琀漀渀
13、挀攀渀琀爀愀琀椀漀渀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐盿葭塏豟偧伀伀吀嘀吀夀挀椯匀挀漀瀀漀氀攀琀椀渀f瀯潸皑栀鄀匀伀倀會匀挀漀瀀漀氀攀琀椀渀會愀渀搀匀伀倀會瀀氀甀猀匀挀漀瀀漀氀攀琀椀渀會吀栀攀搀爀甀最猀愀爀攀愀瀀瀀氀椀攀搀椀渀漀昀瘀攀栀椀挀氀攀猀漀氀甀琀椀漀渀匀伀倀猀愀氀椀渀攀匀挀漀瀀漀氀攀琀椀渀匀伀猀琀攀爀椀氀攀眀愀琀攀爀挀瘀椀渀樀攀挀琀椀漀渀猀愀爀攀挀愀爀爀椀攀搀漀甀琀洀椀渀戀攀昀漀爀攀琀栀攀猀琀愀爀琀漀昀琀栀攀琀攀猀琀猀最攀搀洀椀挀攀漀戀琀愀椀渀攀搀匀挀漀瀀漀氀攀琀椀渀猀挀洀椀渀瀀爀椀漀爀琀漀漀戀樀攀挀琀洀攀洀漀爀礀琀攀猀琀瘀攀栀椀挀氀攀匀伀琀伀搀椀氀甀琀攀搀眀椀琀栀漀氀椀瘀攀漀
14、椀氀愀猀爀攀焀甀椀爀攀搀嬀崀栀愀猀渀漀琀椀渀搀攀瀀攀渀搀攀渀琀氀礀挀漀渀昀椀爀洀攀搀琀栀攀愀挀挀甀爀愀挀礀漀昀琀栀攀猀攀洀攀琀栀漀搀猀吀栀攀礀愀爀攀昀漀爀爀攀昀攀爀攀渀挀攀漀渀氀礀罢摏桓蒈伀砀椀搀攀搀攀氀氀漀渀最攀瘀瀀爀匀攀攀洀漀爀攀挀甀猀琀漀洀攀爀瘀愀氀椀搀愀琀椀漀渀猀漀渀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀刀刀一匀嬀崀漀爀渀椀挀欀攀琀愀氀吀栀攀挀漀甀洀愀爀椀渀匀挀漀瀀漀氀攀琀椀渀瀀漀琀攀渀琀椀愀琀攀猀愀挀攀琀礀氀挀栀漀氀椀渀攀爀攀氀攀愀猀攀昀爀漀洀猀礀渀愀瀀琀漀猀漀洀攀猀愀洀瀀氀椀昀椀攀猀栀椀瀀瀀漀挀愀洀瀀愀氀氀漀渀
15、最琀攀爀洀瀀漀琀攀渀琀椀愀琀椀漀渀愀渀搀愀洀攀氀椀漀爀愀琀攀猀愀渀琀椀挀栀漀氀椀渀攀爀最椀挀愀渀搀愀最攀椀洀瀀愀椀爀攀搀洀攀洀漀爀礀一攀甀爀漀猀挀椀攀渀挀攀攀挀嬀崀椀甀堀攀琀愀氀昀昀攀挀琀漀昀匀挀漀瀀漀氀攀琀椀渀漀渀倀挀攀氀氀瀀爀漀氀椀昀攀爀愀琀椀漀渀愀渀搀愀瀀漀瀀琀漀猀椀猀挀琀愀倀栀愀爀洀愀挀漀氀匀椀渀伀挀琀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶攀搀栀攀洀砀瀀爀攀
16、猀猀匀渀7:s胔-沠鑻.棙?i缀$Secretoneurin-rat-DataSheet-MedChemExpress.pdfpic1.gifSecretoneurinratDataSheetMedChemExpress.pdf2019-102424c7fb74-61a3-4e4d-8cf1-4043b3ca7dbeBdXRnF+AhWsdRUdBdzVzMy+NNZXIxh0VcWLEhHiCk6qjKwoba4Z0YA=Secretoneurin,rat,DataSheet,MedChemExpress73bc7298fc7a7d37d2f75c87b15b38b7Hotline: 400
17、-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESecretoneurin, ratCat. No.: HY-P1764CAS No.: 149146-12-3分式: CHNO分量: 3651.95Sequence: ThrAsnGluIleValGluGluGlnTyrThrProGlnSerLeuAlaThrLeuGluSerValPheGlnGluLeuGlyLysLeuThrGlyProSerAsnGlnSequence Shortening: TNEIVEEQYTPQSLATLESVFQELGKLTGPSNQ作靶
18、点: Others作通路: Others储存式: Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITY物活性 Secretoneurin, rat 是由分泌粒蛋 II (SgII) 的蛋解过程产的种 33 个氨基酸多肽。 Secretoneurin, rat 在体内和体外诱导纹状体多巴胺释放，对单核细胞和嗜酸性粒细胞有很强的趋化作，对粒细胞则没有 1。REFERENCES1. Troger J, et al. Secretoneurin in the peripheral
19、 ocular innervation. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):647-54.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE1/1 Master of Small Molecules 您边的抑制剂师MedChemExpress000
20、1200001可研报告20191024160325222465S(蠀搀翾脠蠀讀缁缀孬節貔%頀h鰀椀輂崂攑礑脑脑脑匑攀渀欀琀椀搀攀开一攀甀爀漀欀椀渀椀渀刀攀挀攀瀀琀漀爀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀匀攀渀欀琀椀搀攀开一攀甀爀漀欀椀渀椀渀刀攀挀攀瀀琀漀爀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀昀愀愀愀戀挀愀挀挀戀攀昀搀攀儀戀伀圀甀刀椀愀礀最渀攀搀搀搀甀眀儀樀刀夀猀昀渀圀倀栀儀最匀攀渀欀琀椀搀攀开一攀甀爀漀欀椀渀椀渀刀攀挀攀瀀琀漀爀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀愀昀戀昀搀搀搀挀愀愀攀搀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匀挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀
21、搀栀攀洀砀瀀爀攀猀猀挀渀匀攀渀欀琀椀搀攀愀琀一漀夀倀匀一漀萀耠蔀蔠丠蜀传脀脠匠匀攀焀甀攀渀挀攀匀甀挀猀瀀笀攀倀栀攀紀倀栀攀氀礀攀甀攀琀一匀攀焀甀攀渀挀攀匀栀漀爀琀攀渀椀渀最匀甀挀笀攀倀栀攀紀一尀摏瘯一攀甀爀漀欀椀渀椀渀刀攀挀攀瀀琀漀爀尀摏倀刀倀爀漀琀攀椀渀一攀甀爀漀渀愀氀匀椀最渀愀氀椀渀最塐礀攀愀爀猀倀漀眀搀攀爀礀攀愀爀洀漀渀琀栀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀灠湥卣鹙豛匀伀洀最洀洀一攀攀搀甀氀琀爀愀猀漀渀椀挀愀猀猀匀漀氀瘀攀渀琀漀渀挀攀渀琀爀愀琀椀漀渀洀最洀最洀最洀洀洀洀洀洀洀洀洀洀洀洀湨葎蒐盿葭塏豟偧湨葠鹶豛楒豲潾厐葟葒葮跿鵑麋豛鱾葧恓叿蕏鹑豛蒚尯摳叿罙摏蓿葮湨塐慛厐塏葒繶偒葎卶恹偓鶋轏匀伀最
22、琀最琀倀最琀最琀吀眀攀攀渀最琀最琀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀匀椀渀猀愀氀椀渀攀匀蕏鹑豛愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶睞眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀最琀最琀挀漀爀渀漀椀氀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀伀伀吀嘀吀夀挀椯匀攀渀欀琀椀搀攀f一卓嬀崀攀攀最愀渀攀琀愀氀吀栀攀猀攀氀攀挀琀椀瘀攀一爀攀挀攀瀀琀漀爀愀最漀渀椀猀琀猀攀渀欀琀椀搀攀攀砀挀椀琀攀猀愀猀甀戀瀀漀瀀甀氀愀琀椀漀渀漀昀搀漀瀀愀洀椀渀攀猀攀渀猀椀琀椀瘀攀渀攀甀爀漀渀攀猀椀渀琀栀攀爀愀琀猀甀戀猀琀愀渀琀椀愀渀椀最爀愀瀀愀爀猀挀漀洀瀀愀挀琀愀椀渀瘀椀琀爀漀爀倀栀愀爀洀愀挀漀氀愀渀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶攀搀栀攀洀砀瀀爀攀猀猀匀
