1、分子量506.59 溶解性(25C) DMSO 分子式C H N OWater CAS号78860-34-1Ethanol 储存条件3年 -20C 粉末状 生物活性 Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (ECvalues are 3 - 6 M for IRTK and 100 M for IGF1R and EGFR). Increases IR subunit tyrosine phosphorylation and activation of PI 3-kinase and Ak
2、t, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site. 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南) 小鼠大鼠兔豚鼠仓鼠狗 重量 (kg)0.020.151.80.40.0810 体
3、表面积 (m )0.0070.0250.150.050.020.5 K 系数36128520 动物 A (mg/kg) = 动物 B (mg/kg) 动物 B的K 系数 动物 A的K 系数 例如,依据体表面积折算法,将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量,需要将22.4 mg/kg 乘以小鼠的K 系数(3),再除以大鼠的K 系数(6), 得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。 参考文献 Sequential activation of class IB and IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Condliffe, et al. Blood. 2005;106: 1432. PMID: 15878979. Demethylasterriquinone B1 目录号M6662 化学数据 323024 50 2 m m m mm