1、-Amyloid (10-35), amideCat. No.: HY-P1567CAS No.: 181427-66-7Molecular Formula: CHNOSMolecular Weight: 2902.33Target: Amyloid-Pathway: Neuronal SignalingStorage: Please store the product under the recommended conditions in the COA.Solvent (2) -Amyloid (10-35) retains the ability to add to bona fide
2、Alzheimers plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, A(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time
3、 points, some of the peptide exists as an amorphous precipitate. In contrast, the use of -Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogen
4、eous fibrils1.REFERENCESProduct Data Sheet InhibitorsAgonistsScreening Librarieswww.MedChemE11. Benzinger TL, et al. Propagating structure of Alzheimers beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAwww.MedChemE2