1、nformation is based on our current knowledge. However the chemical, physical, and toxicological properties have not beencompletely investigated.12. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.
2、12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in acc
3、ordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)UN number: 2811Class: 6.1Packing group: IIIProper shipping name: Toxi
4、c solids, organic, n.o.s. (XAV939)Marine pollutant: NoPoison Inhalation Hazard: NoIMDGUN number: 2811Class: 6.1Page 5 of 6 www.MedChemEPacking group: IIIEMS-No: F-A, S-AProper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (XAV939)Marine pollutant: NoIATAUN number: 2811Class: 6.1Packing group: IIIPrope
5、r shipping name: Toxic solid, organic, n.o.s. (XAV939)15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers
6、 that exceed the threshold (De Minimis)reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subj
7、ect to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive
8、harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport tobe all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It mustonly be handled by sui
9、tably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safeuse of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling orfrom contact with this product.Caution: Product has not bee
10、n fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: techMedChemEAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAPage 6 of 6 www.MedChemE。二、 建立一套会计人员岗职描述，将每个会计岗位的工作人员应该做什么、怎样做，干到什么程度都给予量化、做好规范。三、为团体创造一个积极向上、充满活力的环境，在干好工作的同时，努
11、力提高每一个人的综合素质，大家互帮互助，团结协作，力争团队整体升级，因为我深深知道：学无止境。如果领导认为我不能胜任这一职位，说明我在某方面做的还不够好，我将努力找出自己的差距，为今后工作的开展奠定基础。不管怎样，我都非常感谢领导提供给我的这次机会。懃懃段。高性能计算资源与数值模式发展需求严重脱节，已成为发展瓶颈。海量数据爆炸增长，但存储管理与价值挖掘能力不足。依托全国综合气象信息共享系统（CIMISS）构建了国家和省级集约化数据环境，初步实现对国家-省级核心业务系统和县级预报综合业务平台的数据支撑；国家级、省级存有的各类气象数据总量约26PB,且近年来气象及相关数据增长明显加速，2016 年
12、各类数据增加超过 1.8PB。随着高分气象卫星发射和高时空分辨率数值模式的发展，气象及相关行业数据日增量将由 2015 年的 6.54TB/日增到 2020 年的 62.53TB/日。 海量数据增长给存储管理、加工处理、信息挖掘工作带来了前所未有的挑战。国家级计算与存储资源分散，各单位共有机房27 个，共有服务器 592 台，存储系统 116 套以及数据库 30 余套，存储容量达 10PB 以上，存储产品超越 2000 种。CIMISS 系统始建于 2009 年，基于传统数据库技术架构，无法满足大规模数据快速处理、高效访问和离线信息挖掘，数据的实时应用价值和历史再分析价值无法发挥。我国对海量气
13、象数据挖掘应用与国外相比还存在明显差距，数据的融合应用不足，气象信息服务产业规模有待提升。据不完全统计，欧洲、美国、日本 2015 年气象数据挖掘应用产生的商业价值分别达到 2600 亿、1600 亿、100 亿美元，而我国不足 15 亿美元。业务系统丰富多样，但应用烟囱孤岛仍然不少。国家、省、IONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis su
14、bstance is considered to be non-hazardous for transpor=Acq. Operator : Yang Qian(LCMS-02) Seq. Line : 16Acq. Instrument : HY-LCMS-02 Location : P2-F-02Injection Date : 9/22/2015 10:22:32 AM Inj : 1Inj Volume : 3.000 lAcq. Method : D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51100-1000MS+3MIN
15、-1.5_(0.02%FA).MLast changed : 9/22/2015 9:17:51 AM by Yang Qian(LCMS-02)Analysis Method : D:AGLIENT 1260METHODBLHM-385_3-H01P(RP-HPLC).MLast changed : 9/23/2015 9:38:47 AM by Yang Qian(LCMS-02)(modified after loading)Method Info : HM-385_3-H01P(RP-HPLC)Catalog No : HY-13775 Batch#10347A-RP-134Addit
16、ional Info : Peak(s) manually integratedmin0.5 1 1.5 2 2.5 3mAU0500100015002000DAD1 B, Sig=214,4 Ref=off (D:AGLIENT.0DATA2015092220150922 2015-09-22 09-17-51CPK2015-921-10347.D)1.584 1.6831.9122.069 2.195 2.861=Area Percent Report =Sorted By : SignalMultiplier : 1.0000Dilution : 1.0000Do not use Mul
17、tiplier & Dilution Factor with ISTDsSignal 1: DAD1 B, Sig=214,4 Ref=offPeak RetTime Type Width Area Height Area # min min mAU*s mAU %-|-|-|-|-|-|-|1 1.584 MM 0.0558 8.62241 2.57470 0.28782 1.683 MM 0.0442 12.15630 4.57993 0.40573 1.912 MM 0.0569 2935.52881 860.12830 97.96634 2.069 MM 0.0462 5.84889
18、2.10808 0.19525 2.195 MM 0.0712 28.07431 6.57170 0.93696 2.861 MM 0.0828 6.23843 1.25514 0.2082Totals : 2996.46915 877.21784=* End of Report *Data File D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51CPK2015-921-10347.DSample Name: CPK2015-921-10347HY-LCMS-02 9/23/2015 9:38:48 AM Yang Qian(LCM
19、S-02) Page 1 of 1=Acq. Operator : Yang Qian(LCMS-02) Seq. Line : 16Acq. Instrument : HY-LCMS-02 Location : P2-F-02Injection Date : 9/22/2015 10:22:32 AM Inj : 1Inj Volume : 3.000 lAcq. Method : D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51100-1000MS+3MIN-1.5_(0.02%FA).MLast changed : 9/22/2
20、015 9:17:51 AM by Yang Qian(LCMS-02)Analysis Method : D:AGLIENT 1260METHODBLHM-385_3-H01P(RP-HPLC).MLast changed : 9/23/2015 9:42:22 AM by Yang Qian(LCMS-02)(modified after loading)Method Info : HM-385_3-H01P(RP-HPLC)Catalog No : HY-13775 Batch#10347A-RP-134Additional Info : Peak(s) manually integra
21、tedmin0.5 1 1.5 2 2.5 302000004000006000008000001000000MSD1 TIC, MS File (D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51CPK2015-921-10347.D) ES-API, Pos, Sc0.5221.906Data File D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51CPK2015-921-10347.DSample Name: CPK2015-921-10347HY-LCMS-02 9/
22、23/2015 9:42:24 AM Yang Qian(LCMS-02) Page 1 of 2MS Signal: MSD1 TIC, MS File, ES-API, Pos, Scan, Frag: 50Spectra averaged over upper half of peaks.Noise Cutoff: 1000 counts.Reportable Ion Abundance: 10%.Retention Mol. WeightTime (MS) MS Area or Ion0.522 6909208 157.05 I1.906 6097456 445.20 I223.10
23、Im/z100 200 300 400 500 600 700 800 9000510152025303540*MSD1 SPC, time=0.487:0.651 of D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51CPK2015-921-10347.D ES-APIMax: 288416158.0157.1m/z100 200 300 400 500 600 700 800 900020406080100*MSD1 SPC, time=1.871:1.944 of D:AGLIENT 1260DATA20150922201509
24、22 2015-09-22 09-17-51CPK2015-921-10347.D ES-API149.1446.2223.1* End of Report *Data File D:AGLIENT 1260DATA2015092220150922 2015-09-22 09-17-51CPK2015-921-10347.DSample Name: CPK2015-921-10 Inhibitors, Agonists, Screening Librarieswww.MedChemESafety Data SheetRevision Date:Oct.-11-2018Print Date: O
25、ct.-11-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name : XL019Catalog No. : HY-13775CAS No. : 945755-56-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses : Laboratory chemicals, manufacture of substances.1.3 Details of the s
26、upplier of the safety data sheetCompany: MedChemExpress USATel: 609-228-6898Fax: 609-228-5909E-mail: 1.4 Emergency telephone numberEmergency Phone #: 609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute t
27、oxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effect
28、s.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose
29、 of contents container to an approved waste disposal plant.2.3 Other hazardsPage 1 of 6 www.MedChemENone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms: XL-019;XL 019Formula: C25H28N6O2Molecular Weight: 444.53CAS No. : 945755-56-64. FIRST AID MEASURES4.1 Description of first aid mea
30、suresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelidswith fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing
31、and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of a
