1、Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE Zofenopril Cat. No.:HY-108321 CAS No.:81872-10-8 分式:CHNOS 分量:429.55 作靶点:Angiotensin-converting Enzyme (ACE) 作通路:Metabolic Enzyme/Protease 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1 month 溶解性数据 体外实验DMSO : 5 mg/
2、mL (11.64 mM; Need ultrasonic) Mass Solvent Concentration 1 mg5 mg10 mg 1 mM2.3280 mL11.6401 mL23.2802 mL 5 mM0.4656 mL2.3280 mL4.6560 mL 10 mM0.2328 mL1.1640 mL2.3280 mL 制备储备液 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。 BIOLOGICAL ACTIVITY 物活性 Zofenopril 是个 angiotensin-converting enzyme (ACE) 抑制剂，
3、其 IC50 值为 81 M。 IC50 at higher concentration P50 values against clonus of some AEDs with the exceptions of diazepam, felbamate, phenobarbital and phenytoin compare with concurrent groups, suggesting an increase in anticonvulsant activity 2. PROTOCOL Cell Assay 1Studies are performed in rabbit renal
4、brush border membrane vesicles in which the uptake of radiolabeled GlySar is examined in the absence and presence of captopril, enalapril, enalaprilat, fosinopril, lisinopril, quinapril, quinaprilat, ramipril and Zofenopril 1. MCE has not independently confirmed the accuracy of these methods. They a
5、re for reference only. Animal Administration 2 Male and female mice weighing 8 to12 g (22 to 26 days old) or 20 to 28 g (48 to 56 days old) are used. Mice are exposed to auditory stimulation, 45, 60 or 120 min following intraperitoneal (i.p.) administration of ACE inhibitors (including Zofenopril) (
6、10 to 100 mg/kg) or vehicle and 45 min following i.p. injection of the AEDs studied. All ACE inhibitors are suspended in a 1% solution of Tween 80 before administration 2. MCE has not independently confirmed the accuracy of these methods. They are for reference only. REFERENCES 1. Lin CJ, et al. Com
7、petitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter. Pharm Res. 1999 May;16(5):609-15. 2. Sarro GD, et al. Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE
8、) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Pharmacol Res. 2012 Mar;65(3):285-96. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE 2/2Master of Small Molecules 您边的抑制剂师
