1、Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE Phosphoramidon Disodium Cat. No.:HY-N2021A CAS No.:164204-38-0 分式:CHNNaOP 分量:587.47 作靶点:Angiotensin-converting Enzyme (ACE); Neprilysin 作通路:Metabolic Enzyme/Protease 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1
2、month 溶解性数据 体外实验H2O : 140 mg/mL (238.31 mM) * “ means soluble, but saturation unknown. Mass Solvent Concentration 1 mg5 mg10 mg 1 mM1.7022 mL8.5111 mL17.0221 mL 5 mM0.3404 mL1.7022 mL3.4044 mL 10 mM0.1702 mL0.8511 mL1.7022 mL 制备储备液 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。 BIOLOGICAL ACTIVITY 物活性
3、 Phosphoramidon Disodium 是属蛋酶 (metalloprotease) 抑制剂 。抑制内素转化酶 (ECE) ，中性肽内切 酶 (NEP) 和管紧张素转换酶 (ACE) 的IC50 值分别为 3.5 ，0.034 和 78 M。 IC50 26Suppl 3:S65-8. 2. Sun Q, et al. Synthesis and enzymatic evaluation of phosphoramidon and its anomer: Anomerization of -l-rhamnose triacetate upon phosphitylation.Bioo
4、rg Med Chem. 2013 Nov 1;21(21):6778-87. 3. Hanson LR, et al. Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.J MolNeurosci. 2011 Mar;43(3):424-7. 4. Bhavsar TM, et al. Phosphoramidon, an endothelin-converting enzyme inhibitor, attenuates lipopolysacch
5、aride-induced acute lung injury.Exp Lung Res. 2008 Mar;34(3):141-54. 5. Matsumaru K, et al. Phosphoramidon, an inhibitor of endothelin-converting enzyme, prevents indomethacin-induced gastric mucosal damage in rats.Life Sci. 1998;62(7):PL79-84. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE 3/3Master of Small Molecules 您边的抑制剂师
