1、譬樀(慸搀欀氒憋慸讀缁吀懁頀h椀鼂洂锋锋霋吋愀氀愀稀漀瀀愀爀椀戀刀匀一刀匀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀吀愀氀愀稀漀瀀愀爀椀戀刀匀一刀匀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀攀攀攀攀搀戀搀攀昀愀挀挀愀挀挀唀焀娀洀挀椀刀堀甀爀稀洀瘀昀一琀伀稀猀洀礀搀刀琀唀眀眀吀愀氀愀稀漀瀀愀爀椀戀一愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀愀昀愀愀愀攀攀戀攀攀挀戀戀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀吀愀氀愀稀漀瀀愀爀椀戀刀匀愀琀一漀夀匀一漀匀礀渀漀渀礀洀猀一刀匀刀匀吀脀褠脀萠舀丠蘀传尀摏瘯倀刀倀尀摏攀氀氀礀挀氀攀一愀洀愀
2、最攀瀀椀最攀渀攀琀椀挀猀塐礀攀愀爀猀倀漀眀搀攀爀礀攀愀爀猀洀漀渀琀栀猀渀猀漀氀瘀攀渀琀洀漀渀琀栀灠湥匀鹙豛匀伀攀洀最洀洀伀倀吀眀攀攀渀猀愀氀椀渀攀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀鶋轏匀伀挀漀爀渀漀椀氀匀蕏鹑豛愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶眀眀眀攀搀栀攀洀匀漀氀甀戀椀氀椀琀礀攀洀最洀洀氀攀愀爀猀漀氀甀琀椀漀渀伀伀吀嘀吀夀挀椯吀愀氀愀稀漀瀀愀爀椀戀刀匀一刀匀吀愀氀愀稀漀瀀愀爀椀戀萀刀匀卦酓倀刀倀萀渀踯吀愀氀愀稀漀瀀愀爀椀戀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶攀搀栀攀洀砀瀀爀攀猀猀一吀礀樀一稀夀攀挀挀椀戀搀搀吀夀匀儀砀稀琀
3、栀嘀最氀欀甀琀伀昀搀儀愀刀眀倀最猀洀眀吀礀溶剂： 10% DMSO 90% (20% SBE-CD in saline) Solubility: 2.5 mg/mL (4.90 mM); Clear solution 体内实验 1/2Master of Small Molecules 您边的抑制剂师 www.MedChemE 3. 请依序添加每种溶剂： 10% DMSO 90% corn oil Solubility: 2.5 mg/mL (4.90 mM); Clear solution BIOLOGICAL ACTIVITY 物活性 Taltobulin盐酸盐是Hemiasterlin类似
4、物, 微管蛋抑制剂和抗体药物偶连体毒素组分 (ADCs cytotoxin)。 REFERENCES 1. Vashist YK, et al. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin. World J Gastroenterol. 2006 Nov 14;12(42):6771-8. 2. Hadaschik BA, et al. Targ
5、eting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin. Int J Cancer. 2008 May 15;122(10):2368-76. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E
6、-mail: techMedChemE 2/2Master of Small Molecules 您边的抑制剂师 MedChemExpress0001200001可研报告20191025090815982682Z5KqLiOAXlZlo/epgJksxMNCeNeryqg3l1mSh4fPO69ZOhqHSj8r4aM9f5HbhC/e0薼譬樀(慸搀欀氒憋慸讀缁吀懁頀h栀$Talazoparib-8R-9S-BMN-673-8R-9S-DataSheet-MedChemExpress.pdfpic1.gifTalazoparib-8R-9S-BMN-673-8R-9S-DataSheet-Me
7、dChemExpress.pdf2019-102577e912ee-edbd-4e2f-83ac-53ca318c055c4UqZmM0ciRXuKA31GKLrFzBM8/mJvFLHM6fN6tOzsmyd4R+KtHDUww=Talazoparib,BMN,673,DataSheet,MedChemExpressa580faa4a7286eeb59ee460658cb99b5Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE Talazoparib 8R,9S Cat. No.:HY-16106
8、A CAS No.:1207456-00-5 Synonyms:BMN-673 (8R,9S); (8R,9S)-LT-673 分式:CHFNO 分量:380.35 作靶点:PARP 作通路:Cell Cycle/DNA Damage; Epigenetics 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -20C1 month 溶解性数据 体外实验DMSO : 50 mg/mL (131.46 mM) H2O : 40% PEG300 5% Tween-80 45% saline Solubility: 2.5 mg/mL (6
9、.57 mM); Clear solution 2. 请依序添加每种溶剂： 10% DMSO 90% corn oil 体内实验 1/2Master of Small Molecules 您边的抑制剂师 www.MedChemE Solubility: 2.5 mg/mL (6.57 mM); Clear solution BIOLOGICAL ACTIVITY 物活性 Talazoparib 8R,9S (BMN-673 8R,9S) 是 Talazoparib 的 8R,9S 对映体，可抑制 PARP1 的活性，IC50 值为 144 nM，活性于 Talazoparib。 IC50 02
10、1-58955995 Fax: 021-53700325 E-mail: techMedChemE 2/2Master of Small Molecules 您边的抑制剂师 MedChemExpress0001200001可研报告20191025090813604678NTyj16JN1zYecciE5bdd/TLY46SIQx/z0thV5glkDutOG6fd4Qa跄儀T(憊匀%憍憊讀缁吀懁頀h椀輂紂紃紃脕脕茕夕揿扫钗楛偛葛簀屝桙搀漀挀砀瀀椀挀最椀昀夀揿扫钗楛偛葛簠屝桙搀漀挀砀尀尀昀挀攀戀攀愀戀戀搀愀攀搀愀戀夀稀昀樀挀最焀圀漀欀甀栀吀昀渀椀一眀椀攀焀栀攀琀焀倀洀戀戀洀椀琀漀欀挀儀夀揿扫钗楛
11、偛葛簀屝桙夀挀扫鐀椀偛簀屝桙攀攀愀攀昀愀挀愀挀戀挀昀戀夀揿扫钗楛偛葛奶揿扫钗楛偛葛簀屝桙籑屝桙夀揿扫钗楛偛葛鐠N舠艦彾糿晟虛魧楎偛籎S腔乏虢罛鐠N罜葔桑葔v桥灒敏g萠楎偛扛Y敓蒑礰靔筢筫衷衙葙捶f荨蔀葔獶楙偛敒晑葛彐虾虓N罯蒕钐盿鹑葔祶衙奦妗偗乏彎絎斏葳祶扙扡l睧斍忿虧絝蒋吀颕折腔葟齶軿裿衙譖鮏祙籎籗桖衳絟賿当静紀慓詗敿虧镓谀衔衙W葙虜奒N葟譶扎扡緿豢虒踀蚈慓祥镎葢虦葒啓齒腜N蒑S彞禋愀彥葨祎羐慓紀譵啓虓槿偛慓彷葨慳踀葙衶衙蚈鼰敓慓腥葝九睳袀敟慑腔葟煶籎籗虧睳秿鞉衟襎摖酜蹵葞槿偛靦襒驛扏蘀癎慓籎葔齶癸裿楙偛帀脀楠慳谀楔偛葛啓獧癜胿聟楦偛萀鵎慛衏腎屝靏橶楏偛楥偛癎楢繛葥褀桛虳楛卲葏鵶0斂槿偛鵛葠
12、f魎潧蒏楶苿偫锰癢楒椰偛齎襱葠荳虒葵荳褀桛鷿楠齎襱葠獬豔筡蹏葎驶砀襙驛蕎葟共貆襎蹛教葝t靬籎葖敟桧罛虙猀腓Y楛偛葎v籗葙獶摖豙睺袍絟葙鵶獠舀啙汏楹偛楠葲魧楎鵵楦偛啓荫掏葞愀輰瑷葞麟罘鮀葒貚豾蒚齢葱腓唀捜鵹楛偛啓癜熑艏鰀桧铿鹎扒蠀楾偛襛灛楡葲鵶噏腎偡楒偛葎蹎譎敥u魎抍熗虗葙t禋詙蒑睳籒筑福葙共g魎絎汙襢睳敺慑矿慙腓拿扡钐灢睳救慑摗蒑蠀祎葙獶絓葙籞獞褀楺偛葛襶桛蠀蹟屝辀號楛偛葛獶村瘀豴a膗蒉蚁楎偛魧楎艵摙葫鵶蹵粏槿偛扛儀罛钕楛偛葙葙攀葞偎獛楦偛襛桛葡腫橙楏偛g豗玀罛徕腎纉猀慞摎葙衶衙虑N魎娀橣榖偛睎斍慑懿祾暋譥禋N榋偛驖葛獶魣O睎蒈豏葔楎偛癜禀葟譶葒貊祔禋葟譶苿y籎开豎楔偛見灛楡祾葙腹缀祏虙龘扎扡
13、衾楎偛葥椰偛豛襔灛楡R_衾桎沈扎扡罞襎灛楡葲葖煶魒慓扥蘀給汙酵镎詗孷O睎慓楎偛葓v叿魧N膗鞉靛豾膗葟獶楔偛噏蒍獶襺桛楦偛襛栀葙桶f膗葛需蝜愀椀挀稀一爀挀圀爀攀匀吀砀瀀伀攀倀匀渀搀焀匀伀夀嘀搀一伀匀挀搀甀娀欀伀刀騀F憲尡J鸬鸬胔-棙i縀$茩教育组财务工作总结.docxpic1.gif教育组财务工作总结.docx2019-887492c004-2ff6-4f97-8adf-17b286593f30UIiHh8/UEMoBiBAtgo/Ma1O7DKboQ+WVuMJuOBfPf091dFvcKq5F8Q=教育,财务,工作总结9d19919ddb0ccab11a6ddf5382fb4b03林小宇00
14、02000001思想汇报20190808114051853235D5KFA1Memk+R9W+uy6DkwRp8mVsSrW4Cc5FosTR/KHaRroIUZSn5TQmRR5q37Y1lJ瞅耀訔0薿(憞匀憲憞讀缁E吀懁翾頀h怀栀$茨教育组财务工作总结.docxpic1.gif教育组财务工作总结.docx2019-887492c004-2ff6-4f97-8adf-17b286593f30UIiHh8/UEMoBiBAtgo/Ma1O7DKboQ+WVuMJuOBfPf091dFvcKq5F8Q=教育,财务,工作总结9d19919ddb0ccab11a6ddf5382fb4b03林小宇00
15、02000001思想汇报20190808F(怀憦匀%憲怀憦讀缁吀懁刀屾頀h椀氈技醖屝搀漀挀砀瀀椀挀最椀昀氀技醖屝搀漀挀砀尀尀戀愀愀攀昀昀攀昀愀攀搀愀砀倀吀娀娀儀堀挀挀儀愀倀眀倀戀瘀瀀刀昀儀栀焀瘀礀搀稀娀瀀一甀焀椀漀堀眀氀技醖屝找愀搀愀昀戀搀戀戀搀搀攀攀戀氀技醖屝汾技醖屝軿鹥偻婷紀汙技蒖醖屝盿汔戀醖屝钋襎桛瞏醑扣薖荳瑘脰汬技扴薖荑叿止裿浭詰裿摭楧獟彙腹璀覘奛歭嫿結蔀葑醖葴獶鞕折厐缀璀啟葎瘀璀葎捶榈扒蓿葵谀豛蕘虙稰盿齛稰掋沏翿葑荳残晹湛芌溂覘鉛璀虙潮衦箄葑豔湔厐鱥鱬襶貀盿醉潦璀晹讉騰驥溑抖熏斏汙技腎炍豎罔偵傘鹥撌鮃鑏虙扎縰衶轭醖潮瘀虒罎酎抖酎鐀醖汎技炖虓醖谀臿汬技醖詢奢酎艔啙冁豥鉔兎需蝜搀渀欀礀夀
16、氀樀吀洀戀樀栀礀焀堀伀堀氀戀礀琀氀瘀琀眀焀夀砀儀瀀挀嘀甀氀伀氀伀倀吀戀刀渀7憲俜:逜k阀逜胔-顓6棙i縀$Tanshinone-I-Tanshinone-A-DataSheet-MedChemExpress.pdfpic1.gifTanshinone-I-Tanshinone-A-DataSheet-MedChemExpress.pdf2019-1025dcb5736b-e83d-41b7-8e3f-2173c84c58ad1IaYDLifHqtYh5RPHUon/ChkFdonYET7AbBaCPFvgp+N/BISUnkmmA=Tanshinone,DataSheet,MedChemExp
17、ress44a9e865e37944a6b1fd0667c13209a6Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE Tanshinone I Cat. No.:HY-N0134 CAS No.:568-73-0 Synonyms:Tanshinone A 分式:CHO 分量:276.29 作靶点:Phospholipase 作通路:Metabolic Enzyme/Protease 储存式:-20C3 yearsPowder 4C2 years -80C6 monthsIn solvent -
18、20C1 month 溶解性数据 体外实验DMSO : 2.5 mg/mL (9.05 mM; Need ultrasonic) Mass Solvent Concentration 1 mg5 mg10 mg 1 mM3.6194 mL18.0969 mL36.1939 mL 5 mM0.7239 mL3.6194 mL7.2388 mL 10 mM- 制备储备液 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。 BIOLOGICAL ACTIVITY 物活性 Tanshinone I 是种IIA型重组 sPLA2 和兔重组 cPLA2 抑制剂，IC5
19、0 分别为 11 M 和 82 M。 IC50 16(7):616-20. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemE 3/3Master of Small Molecules 您边的抑制剂师 MedChemExpress0001200001可研报告201910250908186538
20、728kik/poyieLpZkMpYuCnNy2WPwHfNOgndKZ7bgUq85cWYe0n73NT3ZTB/XV2WGmjT0藂帀(萀憠搀欀憳萀憠讀缁吀懁酀頀h椀朂褃褃褃各愀爀椀焀甀椀搀愀爀堀刀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀吀愀爀椀焀甀椀搀愀爀堀刀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀搀戀昀攀挀搀戀愀搀愀昀戀挀儀夀挀昀爀儀渀最礀挀栀圀戀挀爀甀最娀渀吀爀礀砀刀爀搀夀夀匀瀀堀稀唀眀吀愀爀椀焀甀椀搀愀爀堀刀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀愀戀愀昀戀攀攀昀愀搀戀戀昀愀愀昀攀攀B栀*攀搀栀攀洀砀瀀爀攀猀猀一挀椀挀礀焀搀爀倀栀爀唀吀礀漀稀爀猀匀一搀刀爀
21、瀀砀欀欀伀洀夀甀漀爀最娀圀爀樀爀吀瞅耀訔0薿(憞匀憲憞讀缁E吀懁翾頀h怀栀$茨教育组财务工作总结.docxpic1.gif教育组财务工作总结.docx2019-887492c004-2ff6-4f97-8adf-17b286593f30UIiHh8/UEMoBiBAtgo/Ma1O7DKboQ+WVuMJuOBfPf091dFvcKq5F8Q=教育,财务,工作总结9d19919ddb0ccab11a6ddf5382fb4b03林小宇0002000001思想汇报20190808114051853235D5KFA1Memk+R9W+uy6DkwRp8mVsSrW4Cc5FosTR/KHaRroIU
22、ZSn5TQmRR5q37Y1lJ0薾跄蜀(谀憧搀%瀒憴谀憧讀缁吀懁頀h怀椀弃弃弃鼃蜍蜍褍名愀甀爀漀砀椀挀甀洀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀吀愀甀爀漀砀椀挀甀洀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀昀攀昀愀搀愀戀挀戀礀洀最挀欀甀最唀娀夀吀琀欀栀儀猀砀攀吀唀昀一圀栀夀儀吀樀伀瀀猀刀倀礀最吀愀甀爀漀砀椀挀甀洀愀琀愀匀栀攀攀琀攀搀栀攀洀砀瀀爀攀猀猀挀攀挀挀昀昀戀攀愀攀戀戀搀漀琀氀椀渀攀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀眀眀眀攀搀栀攀洀吀愀甀爀漀砀椀挀甀洀愀琀一漀夀唀匀一漀脀茠脀蠠丠舀传蘀匠脀舀娠渀尀摏瘯伀琀栀攀爀猀尀摏伀琀栀攀爀猀
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24、最栀琀最愀椀渀吀愀甀爀漀砀椀挀甀洀椀猀甀猀攀昀甀氀椀渀愀渀礀愀渀椀洀愀氀爀愀椀猀攀搀愀猀愀瀀攀琀漀爀昀漀爀昀漀漀搀漀爀琀漀瀀爀漀搀甀挀攀愀搀攀猀椀爀攀搀瀀爀漀搀甀挀琀椀渀挀氀甀搀椀渀最洀椀氀欀眀漀漀氀挀愀瘀椀愀爀昀攀愀琀栀攀爀猀渀愀椀氀猀昀甀爀栀漀漀瘀攀猀渀挀爀攀愀猀攀瀀爀漀搀甀挀琀猀攀瘀攀渀椀昀渀漀琀椀渀挀爀攀愀猀攀攀昀昀椀挀椀攀渀挀礀嬀崀刀刀一匀嬀崀吀愀甀戀氀漀礀搀匀洀愀氀氀洀漀氀攀挀甀氀攀猀琀栀愀琀椀渀挀爀攀愀猀攀琀栀攀挀漀渀瘀攀爀猀椀漀渀漀昀昀漀漀搀琀漀戀漀搀礀眀攀椀最栀琀最愀椀渀唀匀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀
25、攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀攀猀鵠蒏酶攀搀栀攀洀砀瀀爀攀猀猀甀倀搀嘀娀戀挀愀椀椀砀刀椀琀氀最娀戀礀吀吀砀洀爀愀刀最栀栀椀焀瀀昀吀蜀(谀憧搀%瀒憴谀憧讀缁吀懁頀h怀栀$Tauroxicum-DataSheet-MedChemExpress.pdfpic1.gifTauroxicum-DataSheet-MedChemExpress.pdf2019-10258b6f7e16-0fad-4353-a22b-871098c3181bymgckugUZFDYTt2kM8h25QsxeTU7+
26、fNWC3h4Y20QTBjOps5R+P8yFg=Tauroxicum,DataSheet,MedChemExpress2c78e216cc06f16f13b17eaeb13bd413Hotline: 400-820-3792 InhibitorsAgonistsScreening Libraries www.MedChemE Tauroxicum Cat. No.:HY-U00291 CAS No.:648922-41-2 分式:CHNOS/Zn 分量:362.32 作靶点:Others 作通路:Others 储存式:Please store the product under the r
27、ecommended conditions in the COA. BIOLOGICAL ACTIVITY 物活性 Tauroxicum 可以作为种毒的抗菌剂，替代或补充家畜饲养动物的抗素，来提健康、产、饲料 转化效率和增加体重。 体外研究 Tauroxicum can be used as a nontoxic, non-antimicrobial agent that can replace or supplement the use of antibiotics in the animal husbandry of livestock animals to increase health and general well-being, productivity, feed efficiency and weight gain. Tauroxicum is useful in any animal raised as a pet or for food or to produce a desired product, including milk, wool, caviar, feathers, nails, fur, hooves. Increase
