1、分子量308.42 溶解性（25C） DMSO 分子式C H N OWater CAS号1361532-00-4Ethanol 储存条件3年 -20C 粉末状 生物活性 AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an ICof 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydr
2、olase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells. The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppres
3、sor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimers disease. AA74-1 is the first selective tool for studying APEH activity. 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南） 小鼠大鼠兔豚鼠仓鼠狗 重量 (kg)0.020.151.80.40.0810 体表面积 (m )0.0070.0250.150.050.020.5 K 系数36128520 动物 A (mg/kg) = 动物 B (mg/kg) 动物 B的K 系数 动物 A的K 系数 例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K 系数（3），再除以大鼠的K 系数（6）， 得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。 AA74-1 目录号M8304 化学数据 162842 50 2 m m m mm
