1、分子量209.2 溶解性（25C） DMSO 分子式C H NOWater CAS号37630-20-9Ethanol 储存条件3年 -20C 粉末状 生物活性 CID 5380390 (trans-2,3-Dimethoxy-nitrostyrene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in trans
2、cription, chromatin modification, and signal transduction. CID 5380390 has an ICvalues of 23 M for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM) -binding cysteine present only in the Type I PR
3、MTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases. 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南） 小鼠大鼠兔豚鼠仓鼠狗 重量 (kg)0.020.151.80.40.0810 体表面积 (m )0.0070.0250.150.050.020.5 K 系数36128520 动物 A (mg/kg) = 动物 B (mg/kg) 动物 B的K 系数 动物 A的K 系数 例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K 系数（3），再除以大鼠的K 系数（6）， 得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。 CID 5380390 目录号M8379 化学数据 10114 50 2 m m m mm
