1、(諜省搀%砀琂諡省諜省讀缁缀耀螏頀h椀霂挂倀挀攀琀礀氀漀愀爀戀漀砀礀氀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀倀挀攀琀礀氀漀愀爀戀漀砀礀氀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀戀愀攀愀昀搀攀戀攀戀愀樀眀稀甀倀漀洀刀洀匀砀瘀焀琀砀伀吀渀眀挀伀焀漀戀愀砀洀一爀匀眀栀猀刀儀倀挀攀琀礀氀漀愀爀戀漀砀礀氀愀猀攀渀栀椀戀椀琀漀爀攀搀栀攀洀砀瀀爀攀猀猀昀愀搀攀搀攀戀倀愀琀一漀夀匀一漀茀耠茀蔠丠茀传茀尀摏瘯挀攀琀礀氀漀愀爀戀漀砀礀氀愀猀攀尀摏攀琀愀戀漀氀椀挀渀稀礀洀攀倀爀漀琀攀愀猀攀塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀
2、搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯倀f蒀瀯薑皏癓鄀釿鴯谀貚萀渀谀渀罢摏桓蒈即攀攀洀漀爀攀挀甀猀琀漀洀攀爀瘀愀氀椀搀愀琀椀漀渀猀漀渀眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀刀刀一匀嬀崀愀爀眀漀漀搀爀攀琀愀氀猀漀稀礀洀攀渀漀渀猀攀氀攀挀琀椀瘀攀一猀甀戀猀琀椀琀甀琀攀搀戀椀瀀椀瀀攀爀椀搀礀氀挀愀爀戀漀砀愀洀椀搀攀愀挀攀琀礀氀漀挀愀爀戀漀砀礀氀愀猀攀椀渀栀椀戀椀琀漀爀猀爀攀搀甀挀攀琀椀猀猀甀攀洀愀氀漀渀礀氀漀挀漀渀挀攀渀琀爀愀琀椀漀渀猀椀渀栀椀戀椀琀昀愀琀琀礀愀挀椀搀猀礀渀琀栀攀猀椀猀愀渀搀椀渀挀爀攀愀猀攀昀愀琀琀礀愀挀椀搀漀砀椀搀愀琀椀漀渀椀渀挀甀氀琀甀爀攀搀挀攀氀氀猀愀渀搀椀渀攀砀瀀攀爀椀洀攀渀琀
3、愀氀愀渀椀洀愀氀猀椀漀氀栀攀洀匀攀瀀嬀崀夀愀洀愀猀栀椀琀愀吀攀琀愀氀攀猀椀最渀猀礀渀琀栀攀猀椀猀愀渀搀猀琀爀甀挀琀甀爀攀愀挀琀椀瘀椀琀礀爀攀氀愀琀椀漀渀猀栀椀瀀猀漀昀猀瀀椀爀漀氀愀挀琀漀渀攀猀戀攀愀爀椀渀最甀爀攀椀搀漀戀攀渀稀漀琀栀椀漀瀀栀攀渀攀愀猀愀挀攀琀礀氀漀挀愀爀戀漀砀礀氀愀猀攀猀椀渀栀椀戀椀琀漀爀猀椀漀漀爀最攀搀栀攀洀攀琀琀一漀瘀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀攀搀栀攀洀砀瀀爀攀猀猀挀渀愀猀琀攀爀漀昀匀洀愀氀氀漀氀攀挀甀氀
4、攀猀鵠蒏酶偞爀漀搀甀挀琀愀琀愀匀栀攀攀琀渀栀椀戀椀琀漀爀猀最漀渀椀猀琀猀匠挀爀攀攀渀椀渀最椀戀爀愀爀椀攀猀攀瀀愀爀琀洀攀渀琀漀昀椀挀爀漀戀椀漀氀漀最礀愀洀瀀洀洀甀渀漀氀漀最礀匀攀漀甀氀一愀琀椀漀渀愀氀唀渀椀瘀攀爀猀椀琀礀爀愀搀甀愀琀攀匀挀栀漀漀氀甀最眀眀眀攀搀栀攀洀砀瀀爀攀猀猀挀渀攀搀栀攀洀砀瀀爀攀猀猀靓言茀渀7謆省氂:M胔-輀K棙蟘i缀$CP-640186-hydrochloride-Acetyl-CoA-Carboxylase-Inhibitor-MedChemExpress.pdfpic1.gifCP640186hydrochlorideAcetylCoACarboxylaseInhib
5、itorMedChemExpress.pdf2019-625b72eaa56-59d7-4d2a-9178-79a2166cc40evn8yl7KfH9Epgvbv/Xw2AvOEct5Z/J7g/VSAQenPh5ipqINRpifUnQ=CP,640186,hydrochloride,Acetyl,CoA,Carboxylase,Inhibitor,MedChemExpress2e24e2f0edb3ad58c384531879325716CP-640186 hydrochlorideCat. No.: HY-15259ACAS No.: 591778-70-0分式: CHClNO分量:
6、522.08作靶点: Acetyl-CoA Carboxylase作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 48 mg/mL (91.94 mM)* “ means soluble, but saturation unknown.ConcentrationSolvent Mass 1 mg 5 mg 10 mg1 mM 1.9154 mL 9.5771 mL 19.1542 mL5 mM 0.3831 m
7、L 1.9154 mL 3.8308 mL制备储备液10 mM 0.1915 mL 0.9577 mL 1.9154 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液BIOLOGICAL ACTIVITY物活性 CP-640186 hydrochloride是种有效且可透过细胞的 酰辅酶 A羧化酶 ( ACC)抑制剂，抑制肝脏 ACC1和骼肌 ACC2的 IC50为53 nM和61 nM。客户使本产品发表的科研献See more customer validations on www.MedChemEREFERENCESProduct Data Sheet InhibitorsAg
8、onistsScreening Libraries Department of Microbiology 278(39):37099-111.2. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.McePdfHeightCaut
9、ion: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955995 Fax: 021-53700325 E-mail: techMedChemEMaster of Small Molecules 您边的抑制剂师www.MedChemE2MedChemExpress0001500006先进医疗20190625154457848355C7(鐀諽省搀%砀謈省鐀諽省讀缁缀耀螏椀欂較較較夐洐甐甐甐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐鴐
10、鴐鼐倀吀刀攀挀攀瀀琀漀爀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀瀀椀挀最椀昀倀吀刀攀挀攀瀀琀漀爀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀瀀搀昀尀尀戀昀攀挀搀昀戀搀搀攀漀娀礀琀最昀瀀嘀焀挀琀倀堀吀娀堀倀砀渀渀唀樀樀一漀戀嘀吀漀刀爀樀堀儀倀吀刀攀挀攀瀀琀漀爀最漀渀椀猀琀攀搀栀攀洀砀瀀爀攀猀猀攀搀攀攀攀戀愀挀愀戀攀攀愀戀愀倀愀琀一漀夀匀一漀脀蔠脀蜠氀一萀传尀摏瘯吀刀攀挀攀瀀琀漀爀尀摏倀刀倀爀漀琀攀椀渀一攀甀爀漀渀愀氀匀椀最渀愀氀椀渀最塐倀氀攀愀猀攀猀琀漀爀攀琀栀攀瀀爀漀搀甀挀琀甀渀搀攀爀琀栀攀爀攀挀漀洀洀攀渀搀攀搀挀漀渀搀椀琀椀漀渀猀椀渀琀栀攀伀伀伀吀嘀吀夀挀椯倀吀卓吀吀谀吀卓葏瀀谀到刀一匀嬀崀椀最最椀渀
11、猀匀椀氀攀渀椀攀欀猀愀甀圀攀琀愀氀瘀愀氀甀愀琀椀漀渀漀昀挀栀攀洀椀挀愀氀氀礀搀椀瘀攀爀猀攀吀爀攀挀攀瀀琀漀爀愀最漀渀椀猀琀猀漀渀戀攀栀愀瘀椀漀甀爀猀洀漀琀椀瘀愀琀攀搀戀礀昀漀漀搀愀渀搀渀椀挀漀琀椀渀攀愀渀搀漀渀猀椀搀攀攀昀昀攀挀琀瀀爀漀昀椀氀攀猀倀猀礀挀栀漀瀀栀愀爀洀愀挀漀氀漀最礀攀爀氀瀀爀嬀崀匀琀爀漀渀最倀嘀栀爀椀猀琀椀愀渀猀漀渀倀漀甀最栀爀椀搀最攀攀琀愀氀栀礀搀爀漀砀礀琀爀礀瀀琀愀洀椀渀攀爀攀挀攀瀀琀漀爀猀椀渀琀栀攀搀漀爀猀愀氀猀琀爀椀愀琀甀洀洀攀搀椀愀琀攀猀琀爀攀猀猀椀渀搀甀挀攀搀椀渀琀攀爀昀攀爀攀渀挀攀眀椀琀栀渀攀最愀琀椀瘀攀氀礀爀攀椀渀昀漀爀挀攀搀椀渀猀琀爀甀洀攀渀琀愀氀攀猀挀愀瀀攀
12、戀攀栀愀瘀椀漀爀一攀甀爀漀猀挀椀攀渀挀攀攀挀搀漀椀樀渀攀甀爀嬀崀氀攀琀挀栀攀爀倀吀愀洀瀀愀欀攀爀愀猀匀椀渀礀愀爀搀攀琀愀氀栀愀爀愀挀琀攀爀椀稀椀渀最琀栀攀攀昀昀攀挀琀猀漀昀吀爀攀挀攀瀀琀漀爀氀椀最愀渀搀猀漀渀洀漀琀漀爀愀挀琀椀瘀椀琀礀愀渀搀昀攀攀搀椀渀最戀攀栀愀瘀椀漀甀爀椀渀吀爀攀挀攀瀀琀漀爀欀渀漀挀欀漀甀琀洀椀挀攀一攀甀爀漀瀀栀愀爀洀愀挀漀氀漀最礀匀攀瀀搀漀椀樀渀攀甀爀漀瀀栀愀爀洀嬀崀匀椀甀挀椀愀欀栀愀瀀椀渀匀挀愀爀琀栀礀匀攀琀愀氀倀愀猀攀氀攀挀琀椀瘀攀吀愀最漀渀椀猀琀猀栀漀眀猀愀挀琀椀瘀椀琀礀椀渀愀渀椀洀愀氀洀漀搀攀氀猀漀昀愀渀琀椀瀀猀礀挀栀漀琀椀挀愀挀琀椀瘀椀琀礀一攀甀爀漀瀀栀愀爀洀愀挀漀氀漀最礀攀戀挀攀倀搀昀攀椀最栀琀愀甀琀椀漀渀倀爀漀搀甀挀琀栀愀猀渀漀琀戀攀攀渀昀甀氀氀礀瘀愀氀椀搀愀琀攀搀昀漀爀洀攀搀椀挀愀氀愀瀀瀀氀椀挀愀琀椀漀渀猀漀爀爀攀猀攀愀爀挀栀甀猀攀漀渀氀礀吀攀氀愀砀洀愀椀氀琀攀挀栀
